[HTML][HTML] The PTEN–PI3K axis in cancer
A Papa, PP Pandolfi - Biomolecules, 2019 - mdpi.com
The PI3K–AKT–mTOR signal transduction pathway regulates a variety of biological
processes including cell growth, cell cycle progression and proliferation, cellular …
processes including cell growth, cell cycle progression and proliferation, cellular …
[HTML][HTML] PTEN deficiency is associated with reduced sensitivity to mTOR inhibitor in human bladder cancer through the unhampered feedback loop driving PI3K/Akt …
E Seront, A Pinto, C Bouzin, L Bertrand… - British journal of …, 2013 - nature.com
Background: Preclinical studies have shown that PTEN loss enhances sensitivity to
mammalian target of Rapamycin (mTOR) inhibitors because of facilitated PI3K …
mammalian target of Rapamycin (mTOR) inhibitors because of facilitated PI3K …
A multicenter study shows PTEN deletion is strongly associated with seminal vesicle involvement and extracapsular extension in localized prostate cancer
DA Troyer, T Jamaspishvili, W Wei, Z Feng… - The …, 2015 - Wiley Online Library
BACKGROUND Loss of the phosphatase and tensin homolog (PTEN) tumor suppressor
gene is a promising marker of aggressive prostate cancer. Active surveillance and watchful …
gene is a promising marker of aggressive prostate cancer. Active surveillance and watchful …
[HTML][HTML] Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells
J Wang, X Lv, X Guo, Y Dong, P Peng, F Huang… - Oncogenesis, 2021 - nature.com
Abstract The PI3K/AKT/mTOR signaling pathway is constitutively active in PTEN-deficient
cancer cells, and its targeted inhibition has significant anti-tumor effects. However, the …
cancer cells, and its targeted inhibition has significant anti-tumor effects. However, the …
[HTML][HTML] RFP-mediated ubiquitination of PTEN modulates its effect on AKT activation
The PTEN tumor suppressor is a lipid phosphatase that has a central role in regulating the
phosphatidylinositol-3-kinase (PI3K) signal transduction cascade. Nevertheless, the …
phosphatidylinositol-3-kinase (PI3K) signal transduction cascade. Nevertheless, the …
Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis
C Zhong, G Saribekyan, CP Liao, MB Cohen… - Cancer research, 2006 - AACR
Two commonly occurring genetic aberrations of human prostate cancer [ie, overexpression
of a mitogenic polypeptide (fibroblast growth factor 8, isoform b or FGF8b) and loss of …
of a mitogenic polypeptide (fibroblast growth factor 8, isoform b or FGF8b) and loss of …