Respiratory distress syndrome (RDS) is the most frequent pulmonary complication in
preterm infants. RDS incidence differs between genders, which has been called the male …

Alveolar fluid clearance mediates perinatal lung transition to air breathing in newborn
infants, which is accomplished by epithelial Na+ channels (ENaC) and Na-K-ATPase. Male …

Male sex remains an independent risk factor for respiratory distress syndrome (RDS) in
preterm infants. Insufficient Na+ transport-mediated alveolar fluid clearance contributes to …

Purpose Glucocorticoids and progesterone exert stimulatory effects on epithelial Na+
transport, including increased mRNA expression of the participating ion transporters …

Within this review, sex-specific differences in alveolar epithelial functions are discussed with
special focus on preterm infants and the respiratory disorders associated with premature …

The effects of estradiol (E2) and progesterone (P) on alveolar epithelial Na+ transport were
studied in isolated alveolar epithelial cells from 18-to 19-d GA rat fetuses, grown to …

At birth, lung fluid produced during fetal life must be cleared immediately and efficiently
before the first breath takes place, in order for infants to achieve a normal and successful …

Significant progress have been made in understanding the mechanisms of alveolar fluid
clearance at the time of birth and the transition from placental oxygenation to air breathing …

Rationale: Fetal lung liquid secretion is coupled with chloride transport into the lung lumen.
The postnatal clearance of lung liquid is dependent on osmotic force generated by active …

At birth, the infant's lungs must be cleared of fetal lung fluid. This process is mediated
through the activation of airway epithelial sodium channels (ENaC). In animals, ENaC is …