O, 4′‐C‐Ethylene‐bridged nucleic acid (ENA) is a sugar‐modified oligonucleotide with an
ethylene bridge between the 2′‐oxygen and 4′‐carbon of ribose. ENA not only has as …

Novel 2-O, 4-C-ethylene nucleosides have been synthesized as building blocks for
antisense and antigene oligonucleotides. 2-O, 4-C-Ethylene-bridged nucleic acids (ENATM) …

Novel bicyclo nucleosides, 2′-O, 4′-C-ethylene nucleosides and 2′-O, 4′-C-propylene
nucleosides, were synthesized as building blocks for antisense oligonucleotides to further …

To develop antisense oligonucleotides, novel nucleosides, 2′-O, 4′-C-ethylene
nucleosides and their corresponding phosphoramidites, were synthesized as building …

Abstract Oligonucleotides containing 2′-O, 4′-C-ethylene nucleic acids (ENA) have been
proven highly effective for antisense therapeutics. 2′-O, 4′-C-Ethyleneguanosine and its …

Abstract Novel nucleosides, 2′-O, 4′-C-ethylene nucleosides and their corresponding
phosphoramidites, were synthesized as building blocks for antisense oligonucleotides. The …

For gene validation and the development of oligonucleotide agents, 2′-O, 4′-C-ethylene-
bridged nucleic acid (ENA) antisense gapmers are widely available. An in vitro Escherichia …

We studied the properties of 2′-O, 4′-C-ethylene-bridged nucleic acid (ENA)
oligonucleotides as antisense molecules. Compared to a phosphorothioate (PS) DNA and …

Abstract Novel 2′‐O, 4′‐C‐ethylene‐bridged nucleic acid (ENA) analogs with exocyclic
methylene and (R)‐methyl groups at the 6′‐position were synthesized. The obtained 6 …

A large number of chemically modified oligonucleotides (ONs) have been developed for
RNA-based technologies. In most modified RNAs, the characteristic 2′-hydroxyl (2′-OH) …