Leptin is a peptide hormone, mainly known for its role as a mediator of adipose tissue
endocrine functions, such as appetite control and energy homeostasis. In addition, leptin …

Highlights•Obesity is a pandemic condition associated with both risk and prognosis of breast
cancer.•The adipokine leptin is a plausible molecular link between obesity and breast …

Significant correlations between obesity and incidence of various cancers have been
reported. Obesity, considered a mild inflammatory process, is characterized by a high level …

Adipose-tissue-derived signaling molecules, including the adipokines, are emerging as key
candidate molecules that link obesity with cancer. Peritumoral, stromal, adipose tissue and …

Obesity is an important risk factor for postmenopausal breast cancer and also a poor
prognostic factor among cancer patients. Moreover, obesity is associated with a number of …

More than one million new cases of breast cancer are diagnosed worldwide each year and
more than 400,000 deaths are caused by the disease. The origin of this pathology is …

Obesity is associated with an increased risk of breast cancer. A number of adipocytokines
are increased in obesity causing low-level chronic inflammation associated with an …

Leptin is a 16-kDa multifunctional, neuroendocrine peptide hormone secreted by adipocytes
in proportion to total adipose tissue mass, known to control food intake, energy homeostasis …

Leptin is an important regulator of basal metabolism and food intake, with a pivotal role in
obesity. Leptin exerts many different actions on various tissues and systems, including …

Obesity-related breast cancer is an important threat that affects especially post-menopausal
women. The link between obesity and breast cancer seems to be relying on the …