Drug-induced liver injury (DILI) limits the development and application of many therapeutic
compounds and presents major challenges to the pharmaceutical industry and clinical …

Background and aims Being goalkeepers of liver homeostasis, gap junctions are also
involved in hepatotoxicity. However, their role in this process is ambiguous, as gap junctions …

Acetaminophen (APAP) is a widely used antipyretic and analgesic agent. However,
overdosing and sometimes even a recommended dose can lead to serious and conceivably …

Historically, connexin hemichannels have been considered as structural precursors of gap
junctions. However, accumulating evidence points to independent roles for connexin …

Acetaminophen (APAP) hepatotoxicity is the leading cause of acute liver failure in the US.
Although many aspects of the mechanism are known, recent publications suggest that gap …

Connexins are subunits of gap junction channels, which allow direct transfer of ions,
secondary messenger molecules, and other metabolites between contacting cells. Gap …

Alcohol-related liver disease (ALD) accounts for the majority of cirrhosis and liver-related
deaths worldwide. Activation of IFN-regulatory factor (IRF3) initiates alcohol-induced …

Although a plethora of signaling pathways are known to drive the activation of hepatic
stellate cells in liver fibrosis, the involvement of connexin-based communication in this …

Primary hepatocyte cultures suffer from the progressive occurrence of dedifferentiation
followed by spontaneous apoptosis. This is associated with modifications in the expression …

BACKGROUND & AIMS: In cirrhosis, superimposed inflammation often culminates in acute-
on-chronic liver failure (ACLF) but the mechanism underlying this increased sensitivity is not …