There is a tremendous interest in moving siRNA therapeutics into a clinical setting for the
treatment of various diseases. This in itself however depends largely on the availability of …

Over the last decades, gene therapy has emerged as a pioneering therapeutic approach to
treat or prevent several diseases. Among the explored strategies, the short-term silencing of …

RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a
promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small …

Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of
polymers has gained considerable attention for numerous biomedical applications, due …

siRNA technology presents a helpful means of gene silencing in mammalian cells.
Advancement in the field includes enhanced attentiveness in the characterization of target …

Small interfering RNA (siRNA) therapeutics hold great promise to treat a variety of diseases,
as long as they can be delivered safely and effectively into cells. Dendrimers are appealing …

Successful therapeutic implementation of RNA interference critically depends on systems
able to safely and efficiently deliver small interfering RNA (siRNA). Dendrimers are …

The lack of an appropriate intracellular delivery system for therapeutic nucleic acids (TNAs)
is a major problem in molecular biology, biotechnology, and medicine. A relatively new class …

Conspectus Dendrimers, a special family of polymers, are particularly promising materials
for various biomedical applications by virtue of their well-defined dendritic structure and …

This study aimed to identify suitable siRNA delivery systems based on flexible generation 2–
4 triazine dendrimers by correlating physico-chemical and biological in vitro and in vivo …