Getting specialized: presynaptic and postsynaptic dopamine D2 receptors

C De Mei, M Ramos, C Iitaka, E Borrelli - Current opinion in pharmacology, 2009 - Elsevier
Dopamine (DA) signaling controls many physiological functions ranging from locomotion to
hormone secretion, and plays a critical role in addiction. DA elevation, for instance in …

Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors

A Anzalone, JE Lizardi-Ortiz, M Ramos… - Journal of …, 2012 - Soc Neuroscience
Dysfunctions of dopaminergic homeostasis leading to either low or high dopamine (DA)
levels are causally linked to Parkinson's disease, schizophrenia, and addiction. Major sites …

Dopamine D2 receptors in signal transduction and behavior

R Picetti, A Saiardi, TA Samad, Y Bozzi… - Critical Reviews™ in …, 1997 - dl.begellhouse.com
The dopamine D2 receptor belongs to the family of seven transmembrane domain G-protein-
coupled receptors and is highly expressed in the central nervous system and the pituitary …

[HTML][HTML] The dopamine D2 receptor: new surprises from an old friend

A Bonci, FW Hopf - Neuron, 2005 - cell.com
Drugs acting at dopamine D2 receptors (D2R) are commonly used to alleviate symptoms
produced by diseases such as Parkinson's disease, schizophrenia, and depression. A …

Neuronal dopamine D3 receptors: translational implications for preclinical research and CNS disorders

B Kiss, I Laszlovszky, B Krámos, A Visegrády, A Bobok… - Biomolecules, 2021 - mdpi.com
Dopamine (DA), as one of the major neurotransmitters in the central nervous system (CNS)
and periphery, exerts its actions through five types of receptors which belong to two major …

The D3 dopamine receptor in cellular and organismal function

RA Shafer, B Levant - Psychopharmacology, 1998 - Springer
The D 3 dopamine receptor is a member of the family of D 2-like dopamine receptors. Since
the cloning and identification of the D 3 receptor in 1990, considerable progress has been …

Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization

C Fiorentini, C Busi, E Gorruso, C Gotti, PF Spano… - Molecular …, 2008 - ASPET
Colocalization of dopamine D1 (D1R) and D3 receptors (D3R) in specific neuronal
populations suggests that their functional cross-talk might involve direct interactions. Here …

The signaling and pharmacology of the dopamine D1 receptor

J Jones-Tabah, H Mohammad, EG Paulus… - Frontiers in Cellular …, 2022 - frontiersin.org
The dopamine D1 receptor (D1R) is a Gαs/olf-coupled GPCR that is expressed in the
midbrain and forebrain, regulating motor behavior, reward, motivational states, and cognitive …

Dopamine D1-D2 receptor heteromer signaling pathway in the brain: emerging physiological relevance

A Hasbi, BF O'Dowd, SR George - Molecular brain, 2011 - Springer
Dopamine is an important catecholamine neurotransmitter modulating many physiological
functions, and is linked to psychopathology of many diseases such as schizophrenia and …

[HTML][HTML] The dopamine D4 receptor: biochemical and signalling properties

P Rondou, G Haegeman… - Cellular and molecular life …, 2010 - Springer
Dopamine is an important neurotransmitter that regulates several key functions in the brain,
such as motor output, motivation and reward, learning and memory, and endocrine …