The dopamine D2 receptor (D2) system has been implicated in several neurological and
psychiatric disorders, such as schizophrenia and Parkinson's disease. There are two …

Co-localization of dopamine D1 (D1R) and D3 receptors (D3R) in specific neuronal
populations in the striatum and nucleus accumbens suggests that their cross-talk in the …

Compelling evidence indicates that the long (D2L) and the short (D2S) isoform of dopamine
(DA) D2 receptors serve distinct physiological functions in vivo. To address the involvement …

An increase of extracellular dopamine (DA) concentration is a major neurobiological
substrate of the addictive properties of drugs of abuse. In this article we investigated the …

Dopamine D2 receptors contain a cluster of serine residues in the fifth transmembrane
domain that contribute to activation of the receptor as well as to the binding of agonists. We …

Abused drugs (alcohol, heroin, cocaine, tetrahydrocannabinol and nicotine) elicit a variety of
chronically relapsing disorders by interacting with brain reward systems. All of these drugs …

In the search for efficacious pharmacotherapies to treat cocaine addiction much attention
has been given to agents targeting dopamine D1 or D3 receptors because of the …

In the past few years, a number of laboratories have used gene targeting via homologous
recombination to generate mice deficient for key molecules involved in dopaminergic …

Recent advances in molecular biology have resulted in a number of genetically manipulated
mice with defined changes at dopamine receptor and the dopamine transporter (DAT) loci …

Although the dopamine D1-D2 receptor heteromer has emerging physiological relevance
and a postulated role in different neuropsychiatric disorders, such as drug addiction …