Haematopoietic stem cells (HSCs) differ from their committed progeny by relying primarily on
anaerobic glycolysis rather than mitochondrial oxidative phosphorylation for energy …

Quiescent and self‐renewing hematopoietic stem cells (HSCs) rely on glycolysis rather than
on mitochondrial oxidative phosphorylation (OxPHOS) for energy production. HSC reliance …

Highlights•Specific modes of metabolism play important roles in hematopoietic stem cell
(HSC) self-renewal.•Heterogeneity and technical challenges have prevented the elucidation …

Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research
interest, but the metabolic requirements of HSCs and their adaptations to their niches during …

Quiescence is a fundamental property that maintains hematopoietic stem cell (HSC) potency
throughout life. Quiescent HSCs are thought to rely on glycolysis for their energy, but the …

The metabolic requirements of hematopoietic stem cells (HSCs) change with their cell cycle
activity. However, the underlying role of mitochondria remains ill-defined. Here we found …

The hematopoietic system produces new blood cells throughout life. Mature blood cells all
derived from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly …

Hematopoietic stem cells (HSCs) produce most cellular energy through glycolysis rather
than through mitochondrial respiration. Consistent with this notion, mitochondrial mass has …

Background Adult hematopoietic stem cells (HSCs) are maintained in a microenvironment,
known as niche in the endosteal regions of the bone marrow. This stem cell niche with low …

HSCs have a fate choice when they divide; they can self-renew, producing new HSCs, or
produce daughter cells that will mature to become committed cells. Technical challenges …