Referee: S Hill, McMaster University, Hamilton, Canada Folic acid is an essential nutrient
from the B complex group of vitamins. Folate, as a cofactor, is involved in numerous …

Publisher Summary This chapter focuses on the clinical chemistry of folic acid. In the past
decade, vitamin was known by various names such as vitamin B c, folic acid, vitamin M, and …

Folate is the generic term for compounds that have vitamin activity similar to that of
pteroylglutamic acid. Folate acts as a coenzyme in several single carbon transfers involved …

The vitamin folate functions within the cell as a carrier of one-carbon units. The requirement
for one-carbon transfers is ubiquitous and all mammalian cells carry out folate dependent …

The vitamin folate has been largely responsible for a fundamental shift in our perception of
the role of vitamins in maintaining health. Ten years ago, two independent clinical trials …

This paper reviews the chemistry, metabolism, and molecular biology of folic acid, with a
particular emphasis on how it is, or may be, involved in many disease processes. Folic acid …

The importance of proper consumption of dietary folate for human health has been
highlighted by an extensive number of publications over several decades. Fortification of …

Folate functions as a coenzyme to transfer one‐carbon units that are necessary for
deoxythymidylate synthesis, purine synthesis, and various methylation reactions. Ingested …

FOLIC ACID Page 1 Int. J. Biochem. Vol. 20, No. 2, pp. 133-139, 1988 0020-711X/88 $3.00+0.00
Printed in Great Britain. All rights reserved Copyright © 1988 Pergamon Journals Ltd …

The purpose of the present paper is to review our current understanding of the chemistry
and biochemistry of folic acid and related folates, and to discuss their impact on public …