Despite advances in the treatment of schizophrenia over the past half-century, the illness is
frequently associated with a poor outcome. This is principally related to the late identification …

Importance Since the release of theDSM-5diagnosis of attenuated psychosis syndrome
(DSM-5–APS) in 2013, several research studies have investigated its clinical validity …

Background Research on patients at clinical high risk (CHR) for psychosis has so far mainly
focused on those with transition to frank psychosis (CHR-T patients). However, the majority …

Background The main focus of research on clinical high-risk states for psychosis (CHR) has
been the development of algorithms to predict psychosis. Consequently, other outcomes …

Clinical staging improved the possibility of intervening during the psychosis prodrome to
limit progression of illness. The current study aimed to validate a novel 4-stage severity …

The psychosis prodrome, or period of clinical and functional decline leading up to acute
psychosis, offers a unique opportunity for identifying mechanisms of psychosis onset and for …

An accurate detection of individuals at clinical high risk (CHR) for psychosis is a prerequisite
for effective preventive interventions. Several psychometric interviews are available, but their …

Objective: Approximately 20%–35% of individuals 12–35 years old who meet criteria for a
prodromal risk syndrome convert to psychosis within 2 years. However, this estimate ignores …

Prodromal features of the schizophrenia syndrome have been described for a century, and
work in the past two decades has produced a substantial literature based on these features …

Context Early detection and prospective evaluation of clinical high-risk (CHR) individuals
who may develop schizophrenia or other psychotic disorders is critical for predicting …