Bim is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this
family. Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized from the same …

Bim, the Bcl-2 interacting mediator of cell death, is a member of the BH3-only family of pro-
apoptotic proteins. Recent studies have demonstrated that the apoptotic activity of Bim can …

Bim (Bcl-2-interacting mediator of cell death) is a BH3-only protein (BOP), a pro-apoptotic
member of the Bcl-2 protein family. The Bim mRNA undergoes alternate splicing to give rise …

The proapoptotic BH3-only protein Bim is established to be an important mediator of
signaling pathways that induce cell death. Multisite phosphorylation of Bim by several …

The proapoptotic protein Bim is expressed de novo following withdrawal of serum survival
factors. Here, we show that Bim−/− fibroblasts and epithelial cells exhibit reduced cell death …

Proapoptotic Bcl-2 homology 3-only protein Bim plays an important role in Bax/Bak-
mediated cytochrome c release and apoptosis. Here, we provide evidence for a novel …

Survival and death of lymphocytes are regulated by the balance between pro-and
antiapoptotic members of the Bcl-2 family; this is coordinated with the control of cell cycling …

Bim is known to be critical in killing of melanoma cells by inhibition of the RAF/MEK/ERK
pathway. However, the potential role of the most potent apoptosis-inducing isoform of Bim …

The “BH3-only” proapoptotic BCL-2 family members initiate the intrinsic apoptotic pathway.
A small interfering RNA knockdown of BIM confirms this BH3-only member is important for …

Bim (Bcl-2-interacting mediator of cell death) is a member of the BH3 domain-only subgroup
of Bcl-2 family members, for which three splice variants have been described. Bim is …