A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase
(p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including …

At a molecular level, the immune state is controlled through an exhaustive array of
interconnected and tightly controlled series of intracellular signaling pathways (1, 2). This is …

The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

Protein kinases activated by dual phosphorylation on Tyr and Thr (MAP kinases) can be
grouped into two major classes: ERK and JNK. The ERK group regulates multiple targets in …

The cellular response to treatment with proinflammatory cytokines or exposure to
environmental stress is mediated, in part, by the p38 group of mitogen-activated protein …

Protein signaling networks are formed from diverse and inter-connected cell signaling
pathways converging into webs of function and regulation. These signaling pathways both …

The p38 MAP kinases are a family of serine/threonine protein kinases that play important
roles in cellular responses to external stress signals. Since their identification about 10 years …

The SAPKs represent novel conduits through which the effects of cellular insults or injury are
transmitted to the nucleus to influence gene expression. The SAPK pathway consists of at …

The p38 mitogen-activated protein (MAP) kinase defines a subgroup of the mammalian MAP
kinases that are induced in response to lipopolysaccharide, hyperosmolarity, and interleukin …

The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress
stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the …