The p38 MAPK and heat shock protein 27 (hsp27) form a signaling complex with
serine/threonine kinase Akt and MAPK-activated protein kinase-2 (MK2), which plays an …

The mitogen-activated protein kinase (MAPK) pathways are known to be involved in various
processes of growth, differentiation and cell death. In spite of their ubiquitous presence and …

The mammalian response to stress is complex, often involving multiple signalling pathways
that act in concert to influence cell fate. To examine potential interactions between the …

Two chromatographically distinct stress‐activated protein kinase kinases (SAPKKs) have
been identified in several mammalian cells, termed SAPKK2 and SAPKK3, which activate …

The p38 mitogen-activated protein kinase (MAPK) participates in intracellular signaling
cascades resulting in inflammatory responses. Therefore, inhibition of the p38 MAPK …

The molecular details of mammalian stress-activated signal transduction pathways have
only begun to be dissected. This, despite the fact that the impact of these pathways on the …

Eukaryotic cells respond to extracellular stimuli by recruiting signal transduction pathways,
many of which employ protein Ser/Thr kinases of the ERK1 family. The ubiquity of ERKs and …

The p38 mitogen-activated protein (MAP) kinase signal transduction pathway is activated by
proinflammatory cytokines and environmental stress. The detection of p38 MAP kinase in the …

We have identified a novel mitogen‐and stress‐activated protein kinase (MSK1) that
contains two protein kinase domains in a single polypeptide. MSK1 is activated in vitro by …

Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has
progressed dramatically. The key advances include (1) identification of p38 MAP kinase …