Evaluation of pH-responsive liposomes containing amino acid-based zwitterionic lipids for improving intracellular drug delivery in vitro and in vivo

Y Obata, S Tajima, S Takeoka - Journal of Controlled Release, 2010 - Elsevier
We developed pH-responsive liposomes containing synthetic glutamic acid-based
zwitterionic lipids and evaluated their properties both in vitro and in vivo with the aim of …

On the formulation of pH-sensitive liposomes with long circulation times

S Simões, JN Moreira, C Fonseca, N Düzgüneş… - Advanced drug delivery …, 2004 - Elsevier
Strategies used to enhance liposome-mediated drug delivery in vivo include the
enhancement of stability and circulation time in the bloodstream, targeting to specific tissues …

Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood

T Ishida, Y Okada, T Kobayashi, H Kiwada - International journal of …, 2006 - Elsevier
We have reported that targeted, pH-sensitive sterically stabilized liposomes are able to
increase the cytotoxicity of DXR in vitro against B lymphoma cells, but the rate of release of …

Trends and developments in liposome drug delivery systems

T Lian, RJY Ho - Journal of pharmaceutical sciences, 2001 - Elsevier
Since the discovery of liposomes or lipid vesicles derived from self‐forming enclosed lipid
bilayers upon hydration, liposome drug delivery systems have played a significant role in …

Liposomal delivery systems: design optimization and current applications

ASA Lila, T Ishida - Biological and pharmaceutical bulletin, 2017 - jstage.jst.go.jp
The liposome, a closed phospholipid bilayered vesicular system, has received considerable
attention as a pharmaceutical carrier of great potential over the past 30 years. The ability of …

Intravenous pretreatment with empty pH gradient liposomes alters the pharmacokinetics and toxicity of doxorubicin through in vivo active drug encapsulation

LD Mayer, J Reamer, MB Bally - Journal of pharmaceutical …, 1999 - Wiley Online Library
Liposomes have been used widely to improve the therapeutic activity of pharmaceutical
agents. The traditional approach for such applications has been to formulate the …

Characterization of cationic liposome formulations designed to exhibit extended plasma residence times and tumor vasculature targeting properties

EA Ho, E Ramsay, M Ginj, M Anantha… - Journal of …, 2010 - Elsevier
Cationic liposomes exhibit a propensity to selectively target tumor-associated blood vessels
demonstrating potential value as anti-cancer drug delivery vehicles. Their utility however, is …

pH‐Sensitive liposomes‐principle and application in cancer therapy

H Karanth, RSR Murthy - Journal of pharmacy and …, 2007 - Wiley Online Library
The purpose of this review is to provide an insight into the different aspects of pH‐sensitive
liposomes. The review consists of 6 parts: the first introduces different types of medications …

pH-responsive cationic liposome for endosomal escape mediated drug delivery

S Rayamajhi, J Marchitto, TDT Nguyen… - Colloids and Surfaces B …, 2020 - Elsevier
Endosomal degradation of the nanoparticle is one of the major biological barriers
associated with the drug delivery system. Nanoparticles are internalized in the cell via …

[HTML][HTML] Formation strategies, mechanism of intracellular delivery and potential clinical applications of pH-sensitive liposomes

X Liu, G Huang - Asian journal of pharmaceutical sciences, 2013 - Elsevier
Abstract pH-sensitive liposomes are designed to specifically triggered release the loaded
drugs in response to the change of pH in the surrounding serum. So pH-sensitive liposomes …