Evaluation of pH-responsive liposomes containing amino acid-based zwitterionic lipids for improving intracellular drug delivery in vitro and in vivo
We developed pH-responsive liposomes containing synthetic glutamic acid-based
zwitterionic lipids and evaluated their properties both in vitro and in vivo with the aim of …
zwitterionic lipids and evaluated their properties both in vitro and in vivo with the aim of …
On the formulation of pH-sensitive liposomes with long circulation times
S Simões, JN Moreira, C Fonseca, N Düzgüneş… - Advanced drug delivery …, 2004 - Elsevier
Strategies used to enhance liposome-mediated drug delivery in vivo include the
enhancement of stability and circulation time in the bloodstream, targeting to specific tissues …
enhancement of stability and circulation time in the bloodstream, targeting to specific tissues …
Development of pH-sensitive liposomes that efficiently retain encapsulated doxorubicin (DXR) in blood
T Ishida, Y Okada, T Kobayashi, H Kiwada - International journal of …, 2006 - Elsevier
We have reported that targeted, pH-sensitive sterically stabilized liposomes are able to
increase the cytotoxicity of DXR in vitro against B lymphoma cells, but the rate of release of …
increase the cytotoxicity of DXR in vitro against B lymphoma cells, but the rate of release of …
Trends and developments in liposome drug delivery systems
T Lian, RJY Ho - Journal of pharmaceutical sciences, 2001 - Elsevier
Since the discovery of liposomes or lipid vesicles derived from self‐forming enclosed lipid
bilayers upon hydration, liposome drug delivery systems have played a significant role in …
bilayers upon hydration, liposome drug delivery systems have played a significant role in …
Liposomal delivery systems: design optimization and current applications
ASA Lila, T Ishida - Biological and pharmaceutical bulletin, 2017 - jstage.jst.go.jp
The liposome, a closed phospholipid bilayered vesicular system, has received considerable
attention as a pharmaceutical carrier of great potential over the past 30 years. The ability of …
attention as a pharmaceutical carrier of great potential over the past 30 years. The ability of …
Intravenous pretreatment with empty pH gradient liposomes alters the pharmacokinetics and toxicity of doxorubicin through in vivo active drug encapsulation
Liposomes have been used widely to improve the therapeutic activity of pharmaceutical
agents. The traditional approach for such applications has been to formulate the …
agents. The traditional approach for such applications has been to formulate the …
Characterization of cationic liposome formulations designed to exhibit extended plasma residence times and tumor vasculature targeting properties
Cationic liposomes exhibit a propensity to selectively target tumor-associated blood vessels
demonstrating potential value as anti-cancer drug delivery vehicles. Their utility however, is …
demonstrating potential value as anti-cancer drug delivery vehicles. Their utility however, is …
pH‐Sensitive liposomes‐principle and application in cancer therapy
H Karanth, RSR Murthy - Journal of pharmacy and …, 2007 - Wiley Online Library
The purpose of this review is to provide an insight into the different aspects of pH‐sensitive
liposomes. The review consists of 6 parts: the first introduces different types of medications …
liposomes. The review consists of 6 parts: the first introduces different types of medications …
pH-responsive cationic liposome for endosomal escape mediated drug delivery
S Rayamajhi, J Marchitto, TDT Nguyen… - Colloids and Surfaces B …, 2020 - Elsevier
Endosomal degradation of the nanoparticle is one of the major biological barriers
associated with the drug delivery system. Nanoparticles are internalized in the cell via …
associated with the drug delivery system. Nanoparticles are internalized in the cell via …
[HTML][HTML] Formation strategies, mechanism of intracellular delivery and potential clinical applications of pH-sensitive liposomes
X Liu, G Huang - Asian journal of pharmaceutical sciences, 2013 - Elsevier
Abstract pH-sensitive liposomes are designed to specifically triggered release the loaded
drugs in response to the change of pH in the surrounding serum. So pH-sensitive liposomes …
drugs in response to the change of pH in the surrounding serum. So pH-sensitive liposomes …