Photoreceptor death is the root cause of vision loss in many retinal disorders, and there is an
unmet need for neuroprotective modalities to improve photoreceptor survival. The …

Photoreceptor cell death is the ultimate cause of vision loss in many retinal disorders, and
there is an unmet need for neuroprotective modalities to improve photoreceptor survival …

HK2 and PKM2 are two main regulators of aerobic glycolysis. Photoreceptors (PRs) use
aerobic glycolysis to produce the biomass necessary for the daily renewal of their outer …

Abstract Pyruvate kinase M2 (PKM2) is a glycolytic enzyme that is expressed in cancer cells.
Its role in tumor metabolism is not definitively established, but investigators have suggested …

Pyruvate kinase isozyme type M2 (PKM2), a key glycolytic enzyme, which is involved in ATP
generation and pyruvate production, participates in tumor metabolism, growth, and other …

Photoreceptor death is the ultimate cause of vision loss in many retinal degenerative
conditions. Identifying novel therapeutic avenues for prolonging photoreceptor health and …

Retinitis pigmentosa (RP) is a neurodegenerative disorder that causes irreversible vision
loss in over 1.5 million individuals world-wide. The genetic heterogeneity of RP necessitates …

Acquired and inherited retinal disorders are responsible for vision loss in an increasing
proportion of individuals worldwide. Photoreceptor (PR) death is central to the vision loss …

The main therapeutic goal for diabetic retinopathy (DR) is to prevent vision loss in patients
with diabetes mellitus. Identifying the visual complications at a preclinical juncture will offer …

One hundred years ago, Otto Heinrich Warburg observed that postmitotic retinal cells are the
highest oxygen-consuming cells in the body. He compared these cells to actively growing …