The role of autophagy in osteoarthritis

R Duan, H Xie, ZZ Liu - Frontiers in cell and developmental biology, 2020 - frontiersin.org
Chondrocytes are the only cell type in normal cartilage. The pathological changes of
osteoarthritis (OA) mostly revolve around the apoptosis and dysfunction of chondrocytes …

Characterization of apoptosis in articular cartilage derived from the knee joints of patients with osteoarthritis

G Musumeci, C Loreto, ML Carnazza… - Knee Surgery, Sports …, 2011 - Springer
Purpose The present study was conduced in order to analyse the molecular changes during
the apoptotic cascade in knee articular cartilage of patients with OA. Method Articular …

Mechanisms of chondrocyte apoptosis

M Lotz, S Hashimoto, K Kühn - Osteoarthritis and Cartilage, 1999 - Elsevier
This study addresses the occurrence and significance of chondrocyte apoptosis in the
pathogenesis of cartilage destruction. Chondrocyte apoptosis can be inducedin vitroby nitric …

Pathomechanisms of posttraumatic osteoarthritis: chondrocyte behavior and fate in a precarious environment

J Riegger, RE Brenner - International journal of molecular sciences, 2020 - mdpi.com
Traumatic injuries of the knee joint result in a wide variety of pathomechanisms, which
contribute to the development of so-called posttraumatic osteoarthritis (PTOA). These …

Noncanonical Pyroptosis Triggered by Macrophage‐Derived Extracellular Vesicles in Chondrocytes Leading to Cartilage Catabolism in Osteoarthritis

T Ebata, MA Terkawi, K Kitahara… - Arthritis & …, 2023 - Wiley Online Library
Objective The severity of osteoarthritis (OA) and cartilage degeneration is highly correlated
with the development of synovitis, which is mediated by the activity of inflammatory …

[PDF][PDF] OA cartilage derived chondrocytes encapsulated in poly (ethylene glycol) diacrylate (PEGDA) for the evaluation of cartilage restoration and apoptosis in an in …

G Musumeci, C Loreto, ML Carnazza, I Strehin… - … and histopathology, Vol …, 2011 - hh.um.es
Osteoarthritis (OA) is characterized by cartilage attrition, subchondral bone remodeling,
osteophyte formation and synovial inflammation. Perturbed homeostasis caused by …

Current understanding of osteoarthritis pathogenesis and relevant new approaches

L Tong, H Yu, X Huang, J Shen, G Xiao, L Chen… - Bone research, 2022 - nature.com
Osteoarthritis (OA) is the most common degenerative joint disease that causes painful
swelling and permanent damage to the joints in the body. The molecular mechanisms of OA …

[HTML][HTML] Chondrocyte death by apoptosis is associated with cartilage matrix degradation

CM Thomas, CJ Fuller, CE Whittles, M Sharif - Osteoarthritis and Cartilage, 2007 - Elsevier
OBJECTIVES: To investigate the frequency of chondrocyte apoptosis in equine articular
cartilage (AC) specimens and to examine the relationship between the process of cell death …

Targeting cell death: pyroptosis, ferroptosis, apoptosis and necroptosis in osteoarthritis

J Yang, S Hu, Y Bian, J Yao, D Wang, X Liu… - Frontiers in cell and …, 2022 - frontiersin.org
New research has shown that the development of osteoarthritis (OA) is regulated by different
mechanisms of cell death and types of cytokines. Therefore, elucidating the mechanism of …

PI3K/Akt and caspase pathways mediate oxidative stress-induced chondrocyte apoptosis

D Li, S Ni, KS Miao, C Zhuang - Cell Stress and Chaperones, 2019 - Springer
Chondrocyte apoptosis is closely related to the development and progression of
osteoarthritis (OA); however, the underlying mechanisms remain enigmatic. Previous studies …