Knee osteoarthritis (KOA) is a common chronic disease in orthopedics, which brings great
pain to patients' life and spirit. Therefore, it is necessary to elucidate the pathogenesis of …

OBJECTIVES To investigate whether apoptosis occurs in osteoarthritis (OA), and if this
phenomenon is modulated by human recombinant interleukin 1β (hrIL1β). METHODS …

Osteoarthritis (OA) is the most prevalent joint disease, but neither preventive measures nor
disease-modifying drugs are available and a continuing need exists for safe and effective …

Objective The effect of mechanical injury on chondrocyte viability and matrix degradation
was studied. It was proposed that mechanical injury to human cartilage explants results in …

Osteoarthritis (OA) is a common form of degenerative joint disease. Aging process is
supposed to be a leading predictor for developing OA. In this review, we have discussed the …

Previous studies identified that chondrocyte apoptosis serves an important role in
osteoarthritis (OA). However, the mechanisms of cartilage degeneration induced by …

Apoptosis of articular chondrocytes is associated with the pathogenesis of osteoarthritis
(OA). Recently, we demonstrated that hypoxia-inducible factor (HIF)-2α, encoded by Epas1 …

Degradation of the articular cartilage is at the centre of the pathogenesis of osteoarthritis
(OA), for which age is the major risk factor. Maintaining the chondrocytes in a healthy …

ABSTRACT A switch from autophagy to apoptosis is implicated in chondrocytes during the
osteoarthritis (OA) progression with currently unknown mechanism (s). In this study we …

Chondrocytes of the growth plate undergo apoptosis during the process of endochondral
ossification, as well as during the progression of osteoarthritis. Although the regulation of …