The concept that type I interferons (IFN-I) are essential to antiviral immunity derives from
studies on animal models and cell lines. Virtually all pathogenic viruses have evolved …

The innate immune response is the major front line of defense against viral infections. It
involves hundreds of genes with antiviral properties which expression is induced by type I …

Type III interferon (IFN), or IFN lambda (IFN-λ), is an essential component of the innate
immune response to mucosal viral infections. In both the intestine and the lung, signaling via …

Highlights•Type III interferons are antiviral factors that are expressed in response to
numerous viral infections.•Type III interferons are most crucial for controlling viral infections …

Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to
play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique …

It is currently believed that type I and III interferons (IFNs) have redundant functions.
However, the preferential distribution of type III IFN receptor on epithelial cells suggests …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Over half a century has passed since interferons (IFNs) were discovered and shown to
inhibit virus infection in cultured cells. Since then, researchers have steadily brought to light …

Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as
the first line of defense against virus infection and regulate the development of both innate …

Type I interferons (IFNs) play a central role in the immune defense against viral infections.
Type I IFN signaling is activated by pattern recognition receptors upon sensing of viral …