Apoptosis is a highly regulated cellular process. Aberration in apoptosis is a common
characteristic of various disorders. Therefore, proteins involved in apoptosis are prime …

Senescent cells (SCs) accumulate with age and after genotoxic stress, such as total-body
irradiation (TBI),,,,,. Clearance of SCs in a progeroid mouse model using a transgenic …

Abstract PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug
development platform. However, most PROTACs have been generated empirically because …

Bcr-Abl is the cause of Philadelphia-positive (Ph+) leukemias and also constitutes their
principal therapeutic target, as exemplified by dramatic effects of imatinib mesylate …

Acute myeloid leukemia (AML) remains a clinical challenge. Venetoclax is an effective Bcl-2
selective inhibitor approved by the US Food and Drug Administration (FDA) for treatment of …

Circumvention of apoptotic machinery is one of the distinctive properties of carcinogenesis.
Extensively established key effectors of such apoptotic bypass mechanisms, the …

Highlights•Antiapoptotic BCL-2 proteins are essential to maintain the hematopoietic
system.•BCL-2 protein dependency varies between the different blood cell lineages.•BH3 …

Myelodysplastic syndrome (MDS) transforms into an acute myelogenous leukemia (AML)
with associated increased bone marrow (BM) blast infiltration. Using a transgenic mouse …

Resistance to apoptosis is one of the hallmarks of cancer and members of the B-cell
lymphoma 2 (BCL-2) family of proteins are central regulators of apoptosis. Many cancers …

The B‐cell lymphoma 2 (BCL 2) family of proteins comprise key regulators of apoptosis and
are implicated in the pathogenesis of many malignancies, including lymphomas and …