The ultimate goal of proteomics is determination of the exact chemical composition of protein
species, including their complete amino acid sequence and the identification of each …

The complexity of an organism's proteome is in part due to the diversity of post-translational
modifications present that can direct the location and function of a protein. To address the …

Protein modifications modulate nearly every aspect of cell biology in organisms, ranging
from Archaea to Eukaryotes. The earliest evidence of covalent protein modifications was …

Posttranslational modifications, typically small chemical tags attached on amino acids
following protein biosynthesis, have a profound effect on protein structure and function …

This article highlights the emerging field of chemical proteomics, a powerful technology for
the study of post-and co-translational modification of proteins. Genome mapping and the …

Proteins carry out a wide variety of catalytic, regulatory, signalling and structural functions in
living systems. Following their assembly on ribosomes and throughout their lifetimes, most …

A large array of posttranslational modifications can dramatically change the properties of
proteins and influence different aspects of their biological function such as enzymatic …

The availability of genome sequences, affordable mass spectrometers and high-resolution
two-dimensional gels has made possible the identification of hundreds of proteins from …

Post‐translational modifications (PTMs) are critical to almost all aspects of complex
processes of the cell. Identification of PTMs is one of the biggest challenges for proteomics …

In a proteomics experiment, reduction and alkylation of proteins prior to enzymatic digestion
ensures high sequence coverage of that protein during a database search. However, the …