Tubulogenesis in epithelial organs often initiates with the acquisition of apicobasal polarity,
giving rise to the formation of small lumens that expand and fuse to generate a single …

Abstract Three-dimensional (3D) in vitro kidney tubule models have either largely relied on
the self-morphogenetic properties of the mammalian cells or used an engineered …

Multicellular tubes are structures ubiquitously found during development and in adult
organisms. Their topologies (diameter, direction or branching), together with their …

Adult stem cell-derived organoids are three-dimensional epithelial structures that
recapitulate fundamental aspects of their organ of origin. We describe conditions for the long …

Rebuilding the kidney in the context of tissue engineering offers a major challenge as the
organ is structurally complex and has a high variety of specific functions. Recreation of …

The renal proximal tubule epithelium is responsible for active secretion of endogenous and
exogenous waste products from the body and simultaneous reabsorption of vital compounds …

Scalable fabrication concepts of 3D kidney tissue models are required to enable their
application in pharmaceutical high-throughput screenings. Yet the reconstruction of complex …

Three-dimensional models of kidney tissue that recapitulate human responses are needed
for drug screening, disease modeling, and, ultimately, kidney organ engineering. Here, we …

The lack of engineering systems able to faithfully reproduce complex kidney structures in
vitro has made it difficult to efficiently model kidney diseases and development. Using …

It is estimated that 10% of the worldwide population suffers from chronic kidney disease
(CKD) with a rising tendency. Patients with CKD have limited treatment options and novel …