Abstract Hematopoietic Stem/Progenitor cells (HSPCs) are endowed with the role of
maintaining a diverse pool of blood cells throughout the human life. Despite recent efforts …

Maintenance of the blood system requires balanced cell fate decisions by hematopoietic
stem and progenitor cells (HSPCs). Because cell fate choices are executed at the individual …

Within the bone marrow, stem cells differentiate and give rise to diverse blood cell types and
functions. Currently, hematopoietic progenitors are defined using surface markers combined …

Haematopoietic stem cells (HSCs) are derived early from embryonic precursors, such as
haemogenic endothelial cells and pre-haematopoietic stem cells (pre-HSCs), the molecular …

Regulation of hematopoiesis during human development remains poorly defined. Here we
applied single-cell RNA sequencing (scRNA-seq) and single-cell assay for transposase …

Blood formation is believed to occur through stepwise progression of haematopoietic stem
cells (HSCs) following a tree-like hierarchy of oligo-, bi-and unipotent progenitors. However …

Hematopoietic stem cells (HSCs) are rare cells that arise in the embryo and sustain adult
hematopoiesis. Although the functional potential of nascent HSCs is detectable by …

The dynamics of haematopoietic stem cell differentiation and the hierarchy of oligopotent
stem cells in the bone marrow remain controversial. Here we dissect haematopoietic …

Transcriptome analysis of adult hematopoietic stem cells (HSCs) and their progeny has
revealed mechanisms of blood differentiation and leukemogenesis, but a similar analysis of …

Human hematopoiesis is a dynamic process that starts in utero 18–21 days post-conception.
Understanding the site-and stage-specific variation in hematopoiesis is important if we are to …