A Randomized, Double‐Blind, Placebo‐Controlled Parallel‐Group Study to Assess the Efficacy and Safety of Nebivolol, a Novel β‐Blocker, in Patients With Mild to …

RJ Weiss, MA Weber, AA Carr… - The Journal of Clinical …, 2007 - Wiley Online Library
This double‐blind, multicenter, randomized placebo‐controlled study evaluated the
antihypertensive efficacy and safety of nebivolol, a selective β1‐adrenoreceptor blocker with …

Comparison of Nebivolol monotherapy versus Nebivolol in combination with other antihypertensive therapies for the treatment of hypertension

V Papademetriou - The American journal of cardiology, 2009 - Elsevier
Nebivolol is a novel, β1-adrenergic receptor blocker with vasodilatory properties mediated
through the activation of the l-arginine/nitric oxide pathway. Short-term randomized clinical …

Long-term efficacy of nebivolol monotherapy in patients with hypertension

TJ Cleophas, I Grabowsky, MG Niemeyer… - Current therapeutic …, 2001 - Elsevier
Background: The antihypertensive activity of beta-blockers generally increases during the
first 6 to 8 weeks of treatment; however, no study has systematically assessed whether blood …

Nationwide efficacy-safety study of nebivolol in mildly hypertensive patients

TJ Cleophas, R Agrawal, A Lichtenthal… - American journal of …, 2006 - journals.lww.com
Nebivolol has been adequately tested in clinical efficacy trials of patients with mild
hypertension. Clinical efficacy trials or their metaanalyses did not accurately predict the …

Efficacy and safety of nebivolol in hypertensive patients: a meta-analysis of randomized controlled trials

JY Liu, LN Guo, WZ Peng, Y Jiang… - Journal of …, 2020 - journals.sagepub.com
Purpose Our meta-analysis was undertaken to evaluate the efficacy and safety of nebivolol
compared with other second-generation β blockers for hypertensive patients. Methods We …

Efficacy and tolerability of nebivolol in stage I–II hypertension: a pooled analysis of data from three randomized, placebo-controlled monotherapy trials

RJ Weiss, E Saunders, M Greathouse - Clinical therapeutics, 2011 - Elsevier
BACKGROUND: Nebivolol is a β1-selective β-blocker with NO-mediated vasodilatory
properties, approved in the United States for the treatment of stage I–II hypertension …

A critical review of nebivolol and its fixed-dose combinations in the treatment of hypertension

AFG Cicero, M Kuwabara, C Borghi - Drugs, 2018 - Springer
Abstract β-Adrenergic receptor blockers (β-blockers) are well-known useful and cost-
effective drugs for managing hypertensive patients with coronary heart disease, stroke, and …

Efficacy and tolerability of nebivolol compared with other antihypertensive drugs: a meta-analysis

LM Van Bortel, F Fici, F Mascagni - American Journal of Cardiovascular …, 2008 - Springer
Background and objective Lowering BP to normal levels without quality of life deterioration
is the most important means of reducing cardiovascular risk. Recent studies have …

Nebivolol: in the treatment of hypertension in the US

CM Baldwin, SJ Keam - American journal of cardiovascular drugs, 2009 - Springer
Abstract▲ Nebivolol is a β-adrenergic receptor antagonist with a dual mechanism of action.
It shows high selectivity for β 1-adrenergic receptors and appears to have nitric oxide …

Nebivolol efficacy and safety in patients with stage I‐II hypertension

M Greathouse - … Cardiology: An International Indexed and Peer …, 2010 - Wiley Online Library
Background Nebivolol is a novel, β1‐adrenergic receptor blocker with vasodilatory
properties mediated through activation of the L‐arginine/nitric oxide pathway. Hypothesis …