Little is known of the effects of obesity on ertapenem drug disposition and
pharmacodynamics. Thirty healthy volunteers in three body mass index (BMI) groups (10 per …

Study Objective. To compare the pharmacokinetic and pharmacodynamic profiles of two
dosing regimens for piperacillin‐tazobactam against commonly encountered pathogens …

(1) Background: Piperacillin/tazobactam is a broad-spectrum antimicrobial encompassing
most Gram-positive and Gram-negative aerobic and anaerobic bacteria. The inappropriate …

This is a corrigendum to Clin Pharmacokinet. 2022 Apr 4 An Integral Pharmacokinetic
Analysis of Piperacillin and Tazobactam in Plasma and Urine in Critically Ill Patients …

Objective The study was to establish a population pharmacokinetic (PPK) model of
piperacillin (PIP) and tazobactam (TAZ) that explain pharmacokinetic variability and to …

Objectives: We investigated the population pharmacokinetics and pharmacodynamics of
piperacillin and tazobactam in hospitalized patients. Patients and methods: A multicentre …

Objectives The objectives of this study were to determine the effects of obesity on unbound
trough concentrations and on the achievement of pharmacokinetic (PK)/pharmacodynamic …

The pharmacokinetics and pharmacodynamics of two multiple-dose regimens of piperacillin-
tazobactam (3.375 g every 6 h and 4.5 g every 8 h) were evaluated at steady state for 12 …

What is known and objective Timely and appropriate dosing of antibiotics is essential for the
treatment of bacterial sepsis. Critically ill patients treated with continuous kidney …

Background: Sustained low-efficiency dialysis (SLED), is increasingly being used in
intensive care units (ICUs) but studies informing drug dosing for such patients is lacking …