Piperacillin in combination with tazobactam is one of the most commonly used intravenous
antibiotics. There is evidence for a possible saturable elimination of piperacillin. Therefore …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …

Introduction Ceftazidime is used for the treatment of many bacterial infections, including
severe P. aeruginosa infections. Like other beta-lactams, inter-individual variability in …

Objectives A better dosing strategy can improve clinical outcomes for patients. We sought to
compare the extended or continuous infusion with conventional intermittent infusion of …

Severe sepsis and septic shock can alter the pharmacokinetics of broad-spectrum β-lactams
(meropenem, ceftazidime/cefepime, and piperacillin-tazobactam), resulting in inappropriate …

Purpose Results of a study to determine whether obesity is associated with acute kidney
injury (AKI) among patients receiving combination therapy with piperacillin–tazobactam and …

Background: Antimicrobial pharmacokinetic and pharmacodynamic data are limited in
obesity. Objective: To evaluate the steady-state pharmacokinetics and pharmacodynamics …

Background For more effective and safer usage of antibiotics, the dosing strategy should be
individualized based on the patients' characteristics, including race. The aim of this study …

Study Objective. To compare the effectiveness of extended‐infusion piperacillin‐tazobactam
with that of similar‐spectrum, nonextended‐infusion β‐lactam antibiotics in the treatment of …

Continuous infusion (CI) piperacillin/tazobactam is frequently used to treat infections in very
elderly patients. This study aimed to conduct a population pharmacokinetic analysis of CI …