Background: Sustained low-efficiency dialysis (SLED), is increasingly being used in
intensive care units (ICUs) but studies informing drug dosing for such patients is lacking …

Objectives To evaluate the pharmacokinetics of piperacillin/tazobactam in critically ill
patients undergoing continuous renal replacement therapy (CRRT) and to assess the …

The percentage of the time that the free drug concentration remains above a concentration
threshold (% fT> concentration threshold) has frequently been identified to be the optimal …

Critical illness and extracorporeal circulation, such as extracorporeal membrane
oxygenation (ECMO) and continuous renal replacement therapy (CRRT), may alter the …

Background: In critically ill patients, multi-trauma and intensive therapy can influence the
pharmacokinetics (PK) and pharmacodynamics (PD) of antibiotics with time-dependent …

Piperacillin/tazobactam (TZP) is administered intravenously in a fixed ratio (8: 1) with the
potential for inadequate tazobactam exposure to ensure piperacillin activity against …

Tazobactam is a new derivative of penicillinic acid sulfone, which functions as an
irreversible inhibitor of many β‐lactamases. The disposition of tazobactam M1 metabolite …

Introduction To enhance the probability of pharmacodynamic target attainment, piperacillin–
tazobactam can be administered as either a continuous or extended-infusion dosage …

Despite a number of studies reporting that ertapenem pharmacokinetic parameters differ
considerably in obese patients from those in healthy volunteers, functions describing the …

Drug dosing in obese patients continues to be challenging due to a lack of high‐quality
evidence to guide dosing recommendations. We first published guidance for antibiotic …