Results Sixty-eight participants had data for analysis. Regardless of infusion duration, 6 g/d
piperacillin was associated with≤ 45% target attainment, whereas 12 g/d was associated …

The increased prevalence of obesity presents challenges for clinicians aiming to provide
optimised antimicrobial dosing in the intensive care unit. Obesity is likely to exacerbate the …

Results Forty-two of fifty-five subjects enrolled had complete sampling. Volume of
distribution (median= 0.38 L/kg, intraquartile range= 0.20 L/kg) and elimination rate …

Objectives Despite that piperacillin-tazobactam combination is commonly used in critically ill
children, increasing evidence suggests that the current dosing schedules are not optimal for …

Ertapenem provides broad-spectrum activity against many pathogens, and its use is relevant
for the prophylaxis and treatment of infections in morbidly obese patients undergoing …

Background and importance Continuous infusion of high dose piperacillin/tazobactam (16/2
g in 264 mL NaCl 0.9%) has been included in the UZ Leuven outpatient parenteral …

A piperacillin/tazobactam (PT) restriction was initiated at our institution on 15 July 2012
requiring clinical pharmacy or infectious diseases approval for durations exceeding 72 h. A …

Background: Prolonging the infusion of a β-lactam antibiotic enhances the time in which
unbound drug concentrations remain above the minimum inhibitory concentration (fT> MIC) …

Introduction Recently, complicated intra-abdominal infections (cIAI) have been caused not
only by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, and Pseudomonas …

Purpose The objective of this study was to evaluate the exposure and the pharmacodynamic
target attainment of piperacillin/tazobactam (PTZ) in adult critically ill patients. Methods We …