Discovery and refinement of loci associated with lipid levels
Nature genetics, 2013 - nature.com
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL)
cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for …
cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for …
Biological, clinical and population relevance of 95 loci for blood lipids
TM Teslovich, K Musunuru, AV Smith, AC Edmondson… - Nature, 2010 - nature.com
Plasma concentrations of total cholesterol, low-density lipoprotein cholesterol, high-density
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
lipoprotein cholesterol and triglycerides are among the most important risk factors for …
[HTML][HTML] Comprehensive genetic analysis of the human lipidome identifies loci associated with lipid homeostasis with links to coronary artery disease
We integrated lipidomics and genomics to unravel the genetic architecture of lipid
metabolism and identify genetic variants associated with lipid species putatively in the …
metabolism and identify genetic variants associated with lipid species putatively in the …
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans
S Kathiresan, O Melander, C Guiducci, A Surti… - Nature …, 2008 - nature.com
Blood concentrations of lipoproteins and lipids are heritable risk factors for cardiovascular
disease,. Using genome-wide association data from three studies (n= 8,816 that included …
disease,. Using genome-wide association data from three studies (n= 8,816 that included …
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …
analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for …
Common variants at 30 loci contribute to polygenic dyslipidemia
Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic …
Detailed metabolic and genetic characterization reveals new associations for 30 known lipid loci
T Tukiainen, J Kettunen, AJ Kangas… - Human molecular …, 2012 - academic.oup.com
Almost 100 genetic loci are known to affect serum cholesterol and triglyceride levels. For
many of these loci, the biological function and causal variants remain unknown. We …
many of these loci, the biological function and causal variants remain unknown. We …
Newly identified loci that influence lipid concentrations and risk of coronary artery disease
To identify genetic variants influencing plasma lipid concentrations, we first used genotype
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 …
imputation and meta-analysis to combine three genome-wide scans totaling 8,816 …
[PDF][PDF] Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations
Blood lipid concentrations are heritable risk factors associated with atherosclerosis and
cardiovascular diseases. Lipid traits exhibit considerable variation among populations of …
cardiovascular diseases. Lipid traits exhibit considerable variation among populations of …
[HTML][HTML] Whole genome sequence analysis of blood lipid levels in> 66,000 individuals
Blood lipids are heritable modifiable causal factors for coronary artery disease. Despite well-
described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery …
described monogenic and polygenic bases of dyslipidemia, limitations remain in discovery …