Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies
Several recent reports have described associations between gestational diabetes (GDM)
and changes to the epigenomic landscape where the DNA samples were derived from …
and changes to the epigenomic landscape where the DNA samples were derived from …
Genome-wide DNA methylation profiling in infants born to gestational diabetes mellitus
Background Offspring exposed to gestational diabetes mellitus (GDM) are at a high risk for
metabolic diseases. The mechanisms behind the association between offspring exposed to …
metabolic diseases. The mechanisms behind the association between offspring exposed to …
Maternal gestational diabetes mellitus and newborn DNA methylation: findings from the pregnancy and childhood epigenetics consortium
CG Howe, B Cox, R Fore, J Jungius, T Kvist… - Diabetes …, 2020 - Am Diabetes Assoc
OBJECTIVE Maternal gestational diabetes mellitus (GDM) has been associated with
adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play …
adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play …
Epigenetic signatures of gestational diabetes mellitus on cord blood methylation
Background Intrauterine exposure to gestational diabetes mellitus (GDM) confers a lifelong
increased risk for metabolic and other complex disorders to the offspring. GDM-induced …
increased risk for metabolic and other complex disorders to the offspring. GDM-induced …
Early pregnancy maternal blood DNA methylation in repeat pregnancies and change in gestational diabetes mellitus status—a pilot study
DA Enquobahrie, A Moore, S Muhie… - Reproductive …, 2015 - journals.sagepub.com
Repeat pregnancies with different perinatal outcomes minimize underlying maternal genetic
diversity and provide unique opportunities to investigate nongenetic risk factors and …
diversity and provide unique opportunities to investigate nongenetic risk factors and …
Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases
SM Ruchat, AA Houde, G Voisin, J St-Pierre… - Epigenetics, 2013 - Taylor & Francis
Offspring exposed to gestational diabetes mellitus (GDM) have an increased risk for chronic
diseases, and one promising mechanism for fetal metabolic programming is epigenetics …
diseases, and one promising mechanism for fetal metabolic programming is epigenetics …
DNA methylation profiles in sibling pairs discordant for intrauterine exposure to maternal gestational diabetes
Intrauterine exposure to hyperglycemia is reported to confer increased metabolic risk in later
life, supporting the 'developmental origins of health and disease'hypothesis. Epigenetic …
life, supporting the 'developmental origins of health and disease'hypothesis. Epigenetic …
Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy
Aims/Hypothesis We hypothesized that diabetes during pregnancy (DDP) alters genome-
wide DNA methylation in placenta resulting in differentially methylated loci of metabolically …
wide DNA methylation in placenta resulting in differentially methylated loci of metabolically …
Increased global placental DNA methylation levels are associated with gestational diabetes
C Reichetzeder, SE Dwi Putra, T Pfab, T Slowinski… - Clinical …, 2016 - Springer
Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy
outcomes. It is known that GDM is associated with an altered placental function and changes …
outcomes. It is known that GDM is associated with an altered placental function and changes …
Exposure to Gestational Diabetes Mellitus (GDM) alters DNA methylation in placenta and fetal cord blood
Z Awamleh, DT Butcher, A Hanley… - Diabetes Research and …, 2021 - Elsevier
Background Fetal exposure to maternal GDM increases offspring risk for adult-onset
metabolic syndromes. Epigenetic modifications such as DNA methylation are modulators for …
metabolic syndromes. Epigenetic modifications such as DNA methylation are modulators for …