Maternal genome-wide DNA methylation profiling in gestational diabetes shows distinctive disease-associated changes relative to matched healthy pregnancies

P Wu, WE Farrell, KE Haworth, RD Emes, MO Kitchen… - Epigenetics, 2018 - Taylor & Francis
Several recent reports have described associations between gestational diabetes (GDM)
and changes to the epigenomic landscape where the DNA samples were derived from …

Genome-wide DNA methylation profiling in infants born to gestational diabetes mellitus

X Weng, F Liu, H Zhang, M Kan, T Wang… - Diabetes Research and …, 2018 - Elsevier
Background Offspring exposed to gestational diabetes mellitus (GDM) are at a high risk for
metabolic diseases. The mechanisms behind the association between offspring exposed to …

Maternal gestational diabetes mellitus and newborn DNA methylation: findings from the pregnancy and childhood epigenetics consortium

CG Howe, B Cox, R Fore, J Jungius, T Kvist… - Diabetes …, 2020 - Am Diabetes Assoc
OBJECTIVE Maternal gestational diabetes mellitus (GDM) has been associated with
adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play …

Epigenetic signatures of gestational diabetes mellitus on cord blood methylation

L Haertle, N El Hajj, M Dittrich, T Müller, I Nanda… - Clinical …, 2017 - Springer
Background Intrauterine exposure to gestational diabetes mellitus (GDM) confers a lifelong
increased risk for metabolic and other complex disorders to the offspring. GDM-induced …

Early pregnancy maternal blood DNA methylation in repeat pregnancies and change in gestational diabetes mellitus status—a pilot study

DA Enquobahrie, A Moore, S Muhie… - Reproductive …, 2015 - journals.sagepub.com
Repeat pregnancies with different perinatal outcomes minimize underlying maternal genetic
diversity and provide unique opportunities to investigate nongenetic risk factors and …

Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases

SM Ruchat, AA Houde, G Voisin, J St-Pierre… - Epigenetics, 2013 - Taylor & Francis
Offspring exposed to gestational diabetes mellitus (GDM) have an increased risk for chronic
diseases, and one promising mechanism for fetal metabolic programming is epigenetics …

DNA methylation profiles in sibling pairs discordant for intrauterine exposure to maternal gestational diabetes

E Kim, SH Kwak, HR Chung, JH Ohn, JH Bae… - Epigenetics, 2017 - Taylor & Francis
Intrauterine exposure to hyperglycemia is reported to confer increased metabolic risk in later
life, supporting the 'developmental origins of health and disease'hypothesis. Epigenetic …

Offspring sex impacts DNA methylation and gene expression in placentae from women with diabetes during pregnancy

J Alexander, AM Teague, J Chen, CE Aston, YK Leung… - PloS one, 2018 - journals.plos.org
Aims/Hypothesis We hypothesized that diabetes during pregnancy (DDP) alters genome-
wide DNA methylation in placenta resulting in differentially methylated loci of metabolically …

Increased global placental DNA methylation levels are associated with gestational diabetes

C Reichetzeder, SE Dwi Putra, T Pfab, T Slowinski… - Clinical …, 2016 - Springer
Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy
outcomes. It is known that GDM is associated with an altered placental function and changes …

Exposure to Gestational Diabetes Mellitus (GDM) alters DNA methylation in placenta and fetal cord blood

Z Awamleh, DT Butcher, A Hanley… - Diabetes Research and …, 2021 - Elsevier
Background Fetal exposure to maternal GDM increases offspring risk for adult-onset
metabolic syndromes. Epigenetic modifications such as DNA methylation are modulators for …