Epigenome-wide profiling of DNA methylation in paired samples of adipose tissue and blood
Many epigenetic association studies have attempted to identify DNA methylation markers in
blood that are able to mirror those in target tissues. Although some have suggested potential …
blood that are able to mirror those in target tissues. Although some have suggested potential …
Adjusting for batch effects in DNA methylation microarray data, a lesson learned
EM Price, WP Robinson - Frontiers in genetics, 2018 - frontiersin.org
It is well-known, but frequently overlooked, that low-and high-throughput molecular data may
contain batch effects, ie, systematic technical variation. Confounding of experimental …
contain batch effects, ie, systematic technical variation. Confounding of experimental …
Removing unwanted variation in a differential methylation analysis of Illumina HumanMethylation450 array data
J Maksimovic, JA Gagnon-Bartsch… - Nucleic acids …, 2015 - academic.oup.com
Due to their relatively low-cost per sample and broad, gene-centric coverage of CpGs across
the human genome, Illumina's 450k arrays are widely used in large scale differential …
the human genome, Illumina's 450k arrays are widely used in large scale differential …
EWAS Data Hub: a resource of DNA methylation array data and metadata
Abstract Epigenome-Wide Association Study (EWAS) has become an effective strategy to
explore epigenetic basis of complex traits. Over the past decade, a large amount of …
explore epigenetic basis of complex traits. Over the past decade, a large amount of …
Comprehensive characterization, annotation and innovative use of Infinium DNA methylation BeadChip probes
Abstract Illumina Infinium DNA Methylation BeadChips represent the most widely used
genome-scale DNA methylation assays. Existing strategies for masking Infinium probes …
genome-scale DNA methylation assays. Existing strategies for masking Infinium probes …
SeSAMe: reducing artifactual detection of DNA methylation by Infinium BeadChips in genomic deletions
We report a new class of artifacts in DNA methylation measurements from Illumina
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
HumanMethylation450 and MethylationEPIC arrays. These artifacts reflect failed …
Considerations for normalization of DNA methylation data by Illumina 450K BeadChip assay in population studies
Analysis of epigenetic mechanisms, particularly DNA methylation, is of increasing interest for
epidemiologic studies examining disease etiology and impacts of environmental exposures …
epidemiologic studies examining disease etiology and impacts of environmental exposures …
Meta-analysis of human methylomes reveals stably methylated sequences surrounding CpG islands associated with high gene expression
Background DNA methylation is thought to play an important role in the regulation of
mammalian gene expression, partly based on the observation that a lack of CpG island …
mammalian gene expression, partly based on the observation that a lack of CpG island …
Introduction to epigenomics and epigenome-wide analysis
MJ Fazzari, JM Greally - Statistical Methods in Molecular Biology, 2010 - Springer
Epigenetics is the study of heritable change other than those encoded in DNA sequence.
Cytosine methylation of DNA at CpG dinucleotides is the most well-studied epigenetic …
Cytosine methylation of DNA at CpG dinucleotides is the most well-studied epigenetic …
De novo identification of differentially methylated regions in the human genome
Background The identification and characterisation of differentially methylated regions
(DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We …
(DMRs) between phenotypes in the human genome is of prime interest in epigenetics. We …