Control of oxidative metabolism was studied using 13C NMR spectroscopy to detect rate-
limiting steps in 13C labeling of glutamate. 13C NMR spectra were acquired every 1 or 2min …

Measurements of oxidative metabolism in the heart from dynamic 13C nuclear magnetic
resonance (NMR) spectroscopy rely on 13C turnover in the NMR-detectable glutamate pool …

The pathophysiological state of the cell must be translated into the mitochondria to meet the
demands for oxidative energy production. Metabolite exchange across the mitochondrial …

Rat hearts were perfused with mixtures of [3-13C] pyruvate and [3-13C] lactate (to alter
cytosolic redox) at low (0.5 mM) or high (2.5 mM) Ca2+ concentrations to alter contractility …

Absolute metabolic fluxes in isolated perfused hearts have been determined by a nonlinear
least squares analysis of glutamate labeling kinetics from [1-13 C] glucose,[4-13 C] β …

The nonspecific transaminase inhibitor aminooxyacetate (AOA) has multiple influences on
the dynamics of13C appearance in glutamate in rat hearts as measured by 13C nuclear …

13C-edited proton nuclear magnetic resonance (NMR) spectroscopy was used to follow
enrichment of glutamate C3 and C4 with a temporal resolution of∼ 20 s in mouse hearts …

The appearance of 13C label in glutamate has been used to quantify cellular tricarboxylic
acid (TCA) cycle activity using 13C-NMR spectroscopy. Glutamate is linked to the TCA cycle …

13C-nuclear magnetic resonance (NMR) spectroscopy provides a new approach to the
analysis of metabolic pathways, because it detects an interaction between adjacent 13C …

Although the tricarboxylic acid (TCA) cycle is the prime means of carbon metabolism for
energy generation in normal myocardium, the noninvasive quantification of TCA cycle flux in …