Identifying the downstream targets of microRNAs (miRNAs) is essential to understanding
cellular regulatory networks. We devised a direct biochemical method for miRNA target …

MicroRNAs (miRNAs) have emerged as key gene regulators in diverse biological pathways.
These small non-coding RNAs bind to target sequences in mRNAs, typically resulting in …

MicroRNAs (miRNAs) are a class of small non-coding RNAs that play increasingly
appreciated roles in gene regulation. In animals, miRNAs silence gene expression by …

Comparative genomics analyses and high-throughput experimental studies indicate that a
microRNA (miRNA) binds to hundreds of sites across the transcriptome. Although the …

microRNAs (miRNAs) serve as post-transcriptional regulators of gene expression, by
guiding effector complexes (miRNPs) to target RNAs. Although considerable progress has …

Micro (mi) RNAs are small noncoding RNAs that regulate expression of the majority of the
genes in the genome at either the messenger RNA (mRNA) level (by degrading mRNA) or …

MicroRNAs (miRNAs) suppress gene expression by inhibiting translation, promoting mRNA
decay or both. Each miRNA may regulate hundreds of genes to control the cell's response to …

Target predictions and validations are major obstacles facing microRNA (miRNA)
researchers. Animal miRNA target prediction is challenging because of limited miRNA …

MicroRNAs (miRNAs) are synonymous with post-transcriptional repression of target genes.
A number of studies, however, have reported miRNAs functioning outside this paradigm …

MicroRNAs (miRNAs) are short endogenously expressed RNAs that have the potential to
regulate the expression of any RNA. This potential has led to the publication of several …