Abstract The International Association for the Study of Pain defines neuropathic pain as
“pain arising as a direct consequence of a lesion or disease affecting the somatosensory …

Neuropathic pain can result from injury to, or disease of the nervous system. It is notoriously
difficult to treat. Peripheral nerve injury promotes Schwann cell activation and invasion of …

Neuropathic pain encompasses a broad range of conditions associated with a lesion or
disease of the peripheral or central somatosensory system and its prevalence in the general …

Neuropathic pain is part of the neurological disease spectrum and may be an expression of
severe medical pathology. Painful neuropathies have multiple disguises and may to a …

Peripheral neuropathic pain, that clinical pain syndrome associated with lesions to the
peripheral nervous system, is characterized by positive and negative symptoms. Positive …

Neuropathic pain develops from a lesion or disease affecting the somatosensory system.
Translational investigations of neuropathic pain by using different animal models reveal that …

Preclinical studies have increased our understanding of the pathophysiology of neuropathic
pain at the anatomic, cellular, and molecular levels. These lines of investigation have …

Over the last three decades, the number of research studies devoted to neuropathic pain
has increased dramatically. This expansion of knowledge has generated a number of …

Neuropathic pain is a common problem in clinical practice and one that adversely affects
patients 'quality of life. Converging evidence from animal and human studies demonstrates …

Neuropathic pain refers to pain that originates from pathology of the nervous system.
Diabetes, infection (herpes zoster), nerve compression, nerve trauma, and autoimmune …