Post-transcriptional regulation is a powerful mediator of gene expression, and can rapidly
alter the expression of numerous transcripts involved in tumorigenesis. We have previously …

Increased abundance of the mRNA-binding protein human antigen R (HuR) is a
characteristic feature of many cancers and frequently associated with a high grade …

The development of novel therapeutics that exploit alterations in the activation state of key
cellular signaling pathways due to mutations in upstream regulators has generated the field …

The RNA‐binding protein HuR promotes tumor growth by affecting proliferation, metastasis,
apoptosis, and angiogenesis. Although immune cells, especially tumor‐associated …

Introduction: Despite the current advances in the discovery of the lung cancer biomarkers
and, consequently, in the diagnosis, this pathology continues to be the primary cause of …

Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

Abstract microRNAs are regulatory RNAs that silence specific mRNA by binding to it,
inducing translational repression. Over the recent decades since the discovery of RNA …

Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death. To
explore the potential of small interfering RNA (siRNA) therapy for NSCLC, we have …

Among primary brain cancers, gliomas are the most deadly and most refractory to current
treatment modalities. Previous reports overwhelmingly support the role of the RNA-binding …

There is considerable interest in the use of synthetic miRNA mimics (or inhibitors) as
potential therapeutic agents in pulmonary vascular disease; however, the optimal delivery …