Antimicrobial peptides conjugated with fatty acids on the side chain of D-amino acid promises antimicrobial potency against multidrug-resistant bacteria

C Zhong, N Zhu, Y Zhu, T Liu, S Gou, J Xie… - European Journal of …, 2020 - Elsevier
With the alarming burden of antibiotic resistance, antimicrobial peptides (AMPs) seem to be
novel antimicrobial alternatives for infection treatment due to their rapid broad-spectrum …

Design and synthesis of new N-terminal fatty acid modified-antimicrobial peptide analogues with potent in vitro biological activity

C Zhong, T Liu, S Gou, Y He, N Zhu, Y Zhu… - European Journal of …, 2019 - Elsevier
Developing novel antimicrobial agents is a top priority in fighting against bacterial
resistance. Thus, a series of new monomer and dimer peptides were designed and …

De novo generation of short antimicrobial peptides with enhanced stability and cell specificity

H Kim, JH Jang, SC Kim, JH Cho - Journal of Antimicrobial …, 2014 - academic.oup.com
Abstract Objectives Though antimicrobial peptides (AMPs) show great potential as novel
antibiotics, therapeutic applications are hindered by their low stability, toxicity and high …

Antimicrobial peptides and their analogs: searching for new potential therapeutics

K Midura-Nowaczek… - Perspectives in medicinal …, 2014 - journals.sagepub.com
Antimicrobial peptides (AMPs) are an essential part of innate immunity. These compounds
have been considered as potential therapeutics because of their broad-spectrum activities …

Antimicrobial peptides for therapeutic applications: a review

MD Seo, HS Won, JH Kim, T Mishig-Ochir, BJ Lee - Molecules, 2012 - mdpi.com
Antimicrobial peptides (AMPs) have been considered as potential therapeutic sources of
future antibiotics because of their broad-spectrum activities and different mechanisms of …

A perspective on general direction and challenges facing antimicrobial peptides

M Zhu, P Liu, ZW Niu - Chinese Chemical Letters, 2017 - Elsevier
The emergence of drug resistant bacterium threatens the global public healthcare systems.
The urgent need to obtain new antimicrobials has driven antimicrobial peptides (AMPs) …

Characterization of antimicrobial peptides toward the development of novel antibiotics

W Aoki, M Ueda - Pharmaceuticals, 2013 - mdpi.com
Antimicrobial agents have eradicated many infectious diseases and significantly improved
our living environment. However, abuse of antimicrobial agents has accelerated the …

Ultra-short lipopeptides against gram-positive bacteria while alleviating antimicrobial resistance

C Zhong, F Zhang, N Zhu, Y Zhu, J Yao, S Gou… - European Journal of …, 2021 - Elsevier
Facing the continuously urgent demands for novel antimicrobial agents since the growing
emergence of bacterial resistance, a series of new ultra-short lipopeptides, composed of …

Strategic modification of low-activity natural antimicrobial peptides confers antibacterial potential in vitro and in vivo

PK Hazam, CC Cheng, WC Lin, CY Hsieh… - European Journal of …, 2023 - Elsevier
Antimicrobial peptides (AMPs) show great promise for clinical applications, but the utility of
naturally occurring AMPs is often limited by their stability. Here, we used a rational design …

Antimicrobial peptides (AMPs): peptide structure and mode of action

YK Park, KS Hahm - BMB Reports, 2005 - koreascience.kr
Antimicrobial peptides (AMPs) have been isolated and characterized from tissues and
organisms representing virtually every kingdom and phylum. Their amino acid composition …