Cellular senescence is a potent anti-cancer mechanism that arrests the proliferation of
mitotically competent cells to prevent malignant transformation. Senescent cells accumulate …

The study of cell senescence is a burgeoning field. Senescent cells can modify the cellular
microenvironment through the secretion of a plethora of biologically active products referred …

Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …

Cellular senescence is an established cellular stress response that acts primarily to prevent
the proliferation of cells that experience potentially oncogenic stress. In recent years, it has …

Cellular stress increases progressively with aging in mammalian tissues. Chronic stress
triggers several signaling cascades that can induce a condition called cellular senescence …

Cellular senescence is a state of stable cell cycle arrest that is known to be elicited in
response to different stresses or forms of damage. Senescence limits the replication of old …

Aging is the main risk factor for many degenerative diseases and declining health.
Senescent cells are part of the underlying mechanism for time-dependent tissue dysfunction …

Cellular senescence is the state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli and has therefore long been considered to suppress …

The senescence response is a potent tumor suppressor mechanism characterized by an
irreversible growth arrest in response to potentially oncogenic signals to prevent the …

Cellular senescence is a state of irreversible cell cycle arrest that can be induced by a
variety of potentially oncogenic stimuli, including DNA damage. Hence, senescence has …