O principal desafio na administração transdérmica de fármacos consiste em transpor a
camada córnea, a mais externa da pele. Têm sido desenvolvidas diferentes estratégias …

The skin offers several advantages for the delivery of drugs over conventional routes.
Nevertheless, percutaneous drug delivery, particularly of hydrophilic compounds and …

The transdermal route of administration provides numerous advantages over conventional
routes ie, oral or injectable for the treatment of different diseases and cosmetics applications …

Stratum corneum (SC), the outermost layer of the skin, constitutes an excellent protective
physiological barrier, and is the main challenge in transdermal drug delivery. Many …

This work aimed at designing a formulation based on nanostructured lipid carriers (NLC) for
transdermal co-administration of olanzapine and simvastatin, using passive and active …

The permeation of three drugs from solid lipid nanoparticles (SLN) was assessed using
artificial skin construct (ASC) bio-engineered from human dermal fibroblast (HDF) and …

The delivery of drugs, via different layers of skin, is challenging because it acts as a natural
barrier and exerts hindrance against molecules to permeate into or through it. To overcome …

Dermal and transdermal drug delivery (due to its non-invasiveness, avoidance of the first-
pass metabolism, controlling the rate of drug input over a prolonged time, etc.) have gained …

The ideal drug delivery system has a bioavailability comparable to parenteral dosage forms
but is as convenient and easy to use for the patient as oral solid dosage forms. In recent …

The skin is a complex and multifunctional organ, in which the static versus dynamic balance
is responsible for its constant adaptation to variations in the external environment that is …