The host genotype influences infectious bursal disease virus pathogenesis in chickens by modulation of T cells responses and cytokine gene expression

M Tippenhauer, DE Heller, S Weigend… - Developmental & …, 2013 - Elsevier
The immunopathogenesis of infectious bursal disease virus (IBDV) was investigated in
different layer and broiler type chickens in comparison to highly susceptible specific …

Expression of perforin–granzyme pathway genes in the bursa of infectious bursal disease virus-infected chickens

A Rauf, M Khatri, MV Murgia, YM Saif - Developmental & comparative …, 2011 - Elsevier
Infectious bursal disease (IBD) is an economically important immunosuppressive disease of
chickens. The IBD virus (IBDV) actively replicates in B cells and causes severe bursal …

[HTML][HTML] Changes of CD4+ CD25+ cells ratio in immune organs from chickens challenged with infectious bursal disease virus strains with varying virulences

X Yu, L Rui, Q Shao, H Liu, Y Lu, Y Zhang, Z Li - Viruses, 2015 - mdpi.com
In the current study, we investigate changes in CD4+ CD25+ cells in chickens during
infectious bursal disease virus (IBDV) infection. The percentage of CD4+ CD25+ cells in …

Prokaryotic expression of VP2 protein of infectious bursal disease virus and its immunization evaluation

T LI, D JIANG, P JI, Y WANG… - Journal of Henan …, 2020 - hnnykx.org.cn
In order to improve the purity of infectious bursal disease virus (IBDV) VP2 protein, this study
expressed VP2 protein in Escherichia coli, optimized purification methods and estimated its …

Effective inhibition of infectious bursal disease virus replication in vitro by DNA vector-based RNA interference

Y Gao, W Liu, H Gao, X Qi, H Lin, X Wang, R Shen - Antiviral research, 2008 - Elsevier
Infectious bursal disease (IBD) leads to considerable economic losses for the poultry
industry by inducing severe immunosuppression and high mortality in chickens. The …

Comparative analysis of viral RNA and apoptotic cells in bursae following infection with infectious bursal disease virus

LL Kong, AR Omar, M Hair-Bejo, I Aini… - … and infectious diseases, 2004 - Elsevier
Specific-pathogen-free (SPF) chickens infected with very virulent (vv) infectious bursal
disease virus (IBDV) UPM94/273 developed lower pathogenicity compared to UPM97/61 …

Infectious bursal disease virus tissue tropism and pathogenesis of the infection in chickens by application of in situ PCR, immunoperoxase and HE staining

EA Hussein, M Hair-Bejo, PS Liew, L Adamu… - Microbial …, 2019 - Elsevier
Infectious bursal disease is one of an OIE list of notifiable diseases. Chicken is the only host
that manifests clinical signs and its pathogenicity is correlated with the distribution of …

Effects of IBDV infection on expression of chTLRs in chicken bursa

Y Yu, L Cheng, L Li, Y Zhang, Q Wang, C Ou, Z Xu… - Microbial …, 2019 - Elsevier
Infectious bursal disease virus (IBDV) is the etiological agent of a highly contagious and
immunosuppressive disease that affects domestic chickens. Toll-like receptors (TLRs), a …

Competitive replication of different genotypes of infectious bursal disease virus on chicken embryo fibroblasts

L Shi, H Li, G Ma, J Zhou, L Hong, X Zheng, Y Wu… - Virus Genes, 2009 - Springer
Infectious bursal disease virus (IBDV) causes immunosuppression in chickens. We
investigated the molecular changes in chicken embryo fibroblasts (CEF) adapted IBDV by …

Infectious bursal disease virus infection induces macrophage activation via p38 MAPK and NF-κB pathways

M Khatri, JM Sharma - Virus research, 2006 - Elsevier
In the present study, we show that infection with infectious bursal disease virus (IBDV)
causes activation of macrophages, the key cells involved in inflammatory and immune …