BACKGROUND: The development of reliable gene expression profiling technology is
having an increasing impact on the understanding of breast cancer biology. METHODS: In …

Early detection of breast cancer reduces the suffering and cost to society associated with the
disease. A sensitive assay to identify biomarkers that can accurately diagnose the onset of …

At present, sampling of the lymph nodes or bone marrow for the detection of regions of
metastatic disease in patients with breast cancer can only be undertaken at the time of initial …

Metastases are the major cause of cancer-related deaths in patients with solid epithelial
malignancies, such as breast, colorectal, and prostate carcinomas. Hematogenous …

Background To improve cancer therapy, it is critical to target metastasizing cells. Circulating
tumor cells (CTCs) are rare cells found in the blood of patients with solid tumors and may …

Microarray technologies have made possible comprehensive analyses of nucleic acid
sequence and expression. However, the technology to obtain efficiently high-quality RNA …

The presence of tumor cells in the bone marrow of primary breast cancer patients at surgery
has been shown to be an independent prognostic indicator of relapse. Tumor cells have …

The detection of circulating tumour cells disseminated from solid tumours requires extremely
sensitive methods. Molecular genetic methods, which are most sensitive, are not applicable …

Patients with locally advanced/inflammatory breast cancer (LABC/IBC) face a high
likelyhood of recurrence and prognosis for relapsed, or de novo stage IV metastatic breast …

Breast cancer is a complex genetic disease characterized by the accumulation of multiple
molecular alterations. The resulting clinical heterogeneity makes current diagnostic and …