Regulation of mRNA translation is a rapid and effective means to couple changes in the
cellular environment with global rates of protein synthesis. In response to stresses, such as …

Phosphorylation of eukaryotic initiation factor 2 (eIF2) is an important mechanism regulating
global and gene-specific translation in response to different environmental stresses. Central …

A central mechanism regulating translation initiation in response to environmental stress
involves phosphorylation of the α subunit of eukaryotic initiation factor 2 (eIF2α) …

We discuss novel insight into the role and consequences of the phosphorylation of the
translation initiation factor eIF2α in the context of stress responses and cell-cycle regulation …

In response to environmental stresses, a family of protein kinases phosphorylate eIF2
(eukaryotic initiation factor 2) to alleviate cellular injury or alternatively induce apoptosis …

The accumulation of unfolded/misfolded proteins in the endoplasmic reticulum (ER) causes
stress to which an unfolded protein response is activated to render cell survival or apoptosis …

Stress-induced eukaryotic translation initiation factor 2 (eIF2) α phosphorylation
paradoxically increases translation of the metazoan activating transcription factor 4 (ATF4) …

The endoplasmic reticulum (ER) is the major cellular compartment where folding and
maturation of secretory and membrane proteins take place. When protein folding needs …

Protein kinases that phosphorylate the alpha subunit of eukaryotic initiation factor 2 (eIF2α)
are activated in stressed cells and negatively regulate protein synthesis. Phenotypic …

Significance: Organisms adapt to changing environments by engaging cellular stress
response pathways that serve to restore proteostasis and enhance survival. A primary …