Evidence for free radical damage in Alzheimer's disease includes damage to lipids, proteins,
and nucleic acids and is likely a consequence of redox-active metal accumulations …

It has now been established through multiple lines of evidence that oxidative stress is an
early event in Alzheimer's disease, occurring prior to the canonical cytopathology. Thus …

The two most striking features of Alzheimer disease are (i) the multitude of abnormalities
affecting essentially every system and (ii) the strict age dependence. Recent work suggests …

Over the past decade, the study of oxidative stress in relation to the pathogenesis of
Alzheimer's and other neurodegenerative diseases has been transformed from an esoteric …

The major hurdle in understanding Alzheimer's disease (AD) is a lack of knowledge about
the etiology and pathogenesis of selective neuron death. In recent years, considerable data …

Multiple lines of evidence demonstrate that oxidative stress is an early event in Alzheimer's
disease (AD), occurring prior to cytopathology, and therefore may play a key pathogenic role …

Oxidative stress and damage are accepted features of degenerating and at risk neuronal
populations in Alzheimer disease (Smith et al., 1994a, b, 1995a, 1996a, 1997a, b; Sayre et …

Alzheimer's disease (AD) is the most common form of neurodegenerative disease
associated with dementia in the elderly. Although the initiating events are still unknown, it is …

Over the past decade, oxidative stress has been established as the earliest cytological
feature of Alzheimer disease and an attractive therapeutic target. The major challenges now …

In this review, we consider comparative aspects of the biology and pathology of oxygen
radicals in neurodegenerative disease and how these findings have influenced our concept …