Despite the controversial discussion about amyloid-β as a cause or consequence of
Alzheimer disease pathophysiology, one of the most devastating neurodegenerative …

Oxidative stress, neuroinflammation, insulin signaling deficiency and vascular alterations
are common features of many neurodegenerative disorders. Oxidative damage induces …

Proteins are essential molecules that play crucial roles in maintaining cellular homeostasis
and carrying out biological functions such as catalyzing biochemical reactions, structural …

Alzheimer disease (AD) is a neurodegenerative disease with many known pathological
features, yet there is still much debate into the exact cause and mechanisms for progression …

Reactive oxygen species such as superoxide, hydroxyl radical, nitric oxide, and peroxynitrite
all contribute to cellular oxidative damage when they are in excess of antioxidant defenses …

Publisher Summary Aging and age-related neurological disorders, especially Alzheimer's
disease (AD) and stroke, affect millions of people worldwide. Free radical-associated protein …

The complex nature and genesis of oxidative damage in Alzheimer disease can be partly
answered by mitochondrial and redox-active metal abnormalities. By releasing high levels of …

The pathogenesis of Alzheimer's disease involves β amyloid (Aβ) accumulation known to
induce synaptic dysfunction and neurodegeneration. The brain's vulnerability to oxidative …

Oxidative stress is a striking feature of susceptible neurons in the Alzheimer's disease brain.
Importantly, because oxidative stress is an early event in Alzheimer's disease, proximal to …