The steep relationship between active force and length in cardiac muscle is based on a
length dependence of myofilament Ca2+ sensitivity. However, it is not muscle length but the …

1 To determine the ability of strong‐binding myosin cross‐bridges to activate the myocardial
thin filament, we examined the Ca2+ dependence of force and cross‐bridge interaction …

The basis of the Frank-Starling mechanism of the heart is the increase in active force when
muscle is stretched. Various findings have shown that muscle length, ie, sarcomere length …

Conclusions There is now a large body of evidence in support of the view that Ca 2+ binding
to the low affinity sites of TnC induces a movement of helices B and C away from helices A …

We investigated the mechanism of the Ca2+ sensitivity of cross-bridge transitions that limit
the rate of force development in vertebrate skeletal muscle. The rate of force development …

The steep relationship between systolic force and end diastolic volume in cardiac muscle
(Frank–Starling relation) is, to a large extent, based on length-dependent changes in …

The dependence of contractile properties on intracellular calcium in cardiac tissue is a
highly cooperative process. Here, the temperature and calcium dependence of contractile …

Developmentally regulated alternative RNA splicing generates distinct classes of acidic and
basic troponin T (TnT) isoforms. In fast-twitch skeletal muscles, an acidic-to-basic TnT …

TN-I occurs as a homologous group of proteins which form part of the regulatory system of
vertebrate and invertebrate striated muscle. These proteins are present in vertebrate muscle …

Mutations in titin are responsible for many cardiac and muscle diseases, yet the underlying
mechanisms remain largely unexplained. Numerous studies have established roles for titin …