Phenolic extracts from various Algerian plants as strong inhibitors of porcine liver carboxylesterase

A Djeridane, M Yousfi, B Nadjemi… - Journal of Enzyme …, 2006 - Taylor & Francis
Carboxylesterases (CE), expressed at high levels in human liver and intestine, are thought
to detoxify xenobiotics. The goal of this study was to study the effect of phenolic compounds …

Effect of flavonoids from various Mediterranean plants on enzymatic activity of intestinal carboxylesterase

P Stocker, M Yousfi, O Djerridane, J Perrier, R Amziani… - Biochimie, 2004 - Elsevier
Flavonol compounds of three Mediterranean plants from the Algerian Atlas used traditionally
in Arab folk medicine, Arenaria serpyllifolia, Rhamnus alaternus and Thapsia garganica …

Inhibition of porcine liver carboxylesterase by a new flavone glucoside isolated from Deverra scoparia

A Djeridane, JM Brunel, N Vidal, M Yousfi… - Chemico-Biological …, 2008 - Elsevier
An endemic North African Saharan plant from of the Apiaceae family, Deverra scoparia,
used locally for medicinal preparations, showed a strong inhibitory effect on porcine liver …

Medicinal plants with cholinesterase inhibitory activity: a review

EA Adewusi, N Moodley, V Steenkamp - African Journal of Biotechnology, 2010 - ajol.info
Abstract Alzheimer's disease (AD), a common neurodegenerative disease, is characterized
by low levels in the brain of the neurotransmitter, acetylcholine (ACh). Clinical treatment of …

Nevadensin is a naturally occurring selective inhibitor of human carboxylesterase 1

YQ Wang, ZM Weng, TY Dou, J Hou, DD Wang… - International journal of …, 2018 - Elsevier
Abstract Human carboxylesterase 1 (hCE1) is a key enzyme responsible for the hydrolysis of
a wide range of endogenous and xenobiotic esters, but the highly selective inhibitors …

Synthesis of new carboxylesterase inhibitors and evaluation of potency and water solubility

CE Wheelock, TF Severson… - Chemical research in …, 2001 - ACS Publications
Carboxylesterases are essential enzymes in the hydrolysis and detoxification of numerous
pharmaceuticals and pesticides. They are vital in mediating organophosphate toxicity and in …

Identification and characterization of naturally occurring inhibitors against human carboxylesterase 2 in White Mulberry Root-bark

YJ Liu, SY Li, J Hou, YF Liu, DD Wang, YS Jiang… - Fitoterapia, 2016 - Elsevier
Abstract White Mulberry Root-bark (WMR) is an edible Chinese herbal used for the
treatment of inflammation, nephritis and asthma. This study aimed to investigate the …

Recent progress in the discovery of natural inhibitors against human carboxylesterases

DD Wang, LW Zou, Q Jin, J Hou, GB Ge, L Yang - Fitoterapia, 2017 - Elsevier
Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the
hydrolysis of ester-or amide-containing compounds into the corresponding alcohols and …

Enzyme inhibition effect and polyphenolic content of medicinal plant extracts from Burkina Faso

MJ Bangou, M Kiendrebeogo… - Journal of …, 2011 - ipn.elsevierpure.com
In the present study, 36 plant extracts, belonging to 6 families from Burkina Faso were used
to evaluate their glutathione-S-transferase (GST), acetylcholinesterase (AChE) …

Structure-activity relationships of pentacyclic triterpenoids as potent and selective inhibitors against human carboxylesterase 1

LW Zou, TY Dou, P Wang, W Lei, ZM Weng… - Frontiers in …, 2017 - frontiersin.org
Human carboxylesterase 1 (hCE1), one of the most important serine hydrolases distributed
in liver and adipocytes, plays key roles in endobiotic homeostasis and xenobiotic …