The identity of the cell of origin for pancreatic ductal adenocarcinoma (PDAC) has long been
debated. PDAC has a ductal morphology, but there is no formal proof that it originates from …

The cell of origin of pancreatic cancer has long been controversial. Historically, histological
similarity suggested ductal cells, as reflected in the term 'ductal adenocarcinoma', as the cell …

Pancreatic ductal adenocarcinoma (PDAC) is a devastating type of cancer. While many
studies have shed light into the pathobiology of PDAC, the nature of PDAC's cell of origin …

See “Identification and manipulation of biliary metaplasia in pancreatic tumors,” by
DelGiorno KE, Hall JC, Takeuchi KK, et al, on page 233 and “DCLK1 Marks a …

Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with a 5-year survival rate of
less than 8%. To date, there are no early detection methods or effective treatments available …

The terms cancer-initiating or cancer stem cells have been the subject of great interest in
recent years. In this review we will use pancreatic cancer as an overall theme to draw …

In this issue of Cancer Cell, Guerra and colleagues provide important new insights
regarding the ability of specific pancreatic cell types to generate invasive pancreatic cancer …

Objective Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumour thought
to arise from ductal cells via pancreatic intraepithelial neoplasia (PanIN) precursor lesions …

Pancreatic cancer remains one of the most difficult malignancies to treat. Significant
developments in our understanding of pancreatic cancer biology have occurred over the …

Pancreatic ductal adenocarcinoma (PDA) is especially deadly due to its recalcitrance to
current therapies. One of the unique qualities of PDA that may contribute to this resistance is …