The chemical properties and diversity of volatile isoprenoids lends them to a broad variety of
biological roles. It also lends them to a host of biotechnological applications, both by taking …

Two synthetic approaches to the C29− C44 portion of spongistatin 1 (altohyritin A) have
been developed. The key step of the first approach relies on the Claisen rearrangement of …

Synthetic Studies on Altohyrtins (Spongistatins): Synthesis of the C1-C14 (AB) Spiroacetal Portion
Page 1 TETRAHEDRON LETTERS Tetrahedron Letters 39 (1998) 3795-3798 Pergamon …

The first total synthesis of a spongipyran macrolide, altohyrtin C, is described. The
convergent synthesis strategy relies on a regioselective macrolactonization, a …

A convergent synthesis of the C (1–17) AB-ring subunit of the spongistatins, exceedingly
scarce and highly antimitotic polyether macrolides, has been achieved via a one-flask …

This pathway functions through the double phosphorylation of an isopentenol, either
isoprenol or prenol, to produce the main precursors to isoprenoid synthesis, isopentenyl …

Biosynthesis of the furanic labdane diterpene marrubiin in etiolated shoot cultures of
Marrubium vulgare proceeds via a non-mevalonate pathway. Sterols are built via the …

A major goal of the Leighton group is the synthesis of biologically relevant polyketide natural
products. Among the most potent and chemically intriguing member of this class is …

Starting from the readily available meso‐1, 1′‐methylenebis (8‐oxabicyclo [3.2. 1] oct‐6‐
en‐3‐one)(1), meso‐1, 1′‐methylenebis [(4R, 4′ S, 6R, 6′ S)‐4, 6‐dioxycyclohept‐1‐en …