Amplified micromagnetic field gradients enable high-resolution profiling of rare cell subpopulations

M Poudineh, EH Sargent, SO Kelley - ACS Applied Materials & …, 2017 - ACS Publications
Analyzing small collections of cells is challenging because of the need for extremely high
levels of sensitivity. We recently reported a new approach, termed magnetic ranking …

Nanoparticle amplification labeling for high-performance magnetic cell sorting

Z Wang, H Wang, S Lin, S Ahmed, S Angers… - Nano …, 2022 - ACS Publications
Magnetic cell sorting is an enabling tool for the isolation of specific cellular subpopulations
for downstream applications and requires the cells to be labeled by a sufficient number of …

Microscale magnetic field modulation for enhanced capture and distribution of rare circulating tumor cells

P Chen, YY Huang, K Hoshino, JXJ Zhang - Scientific reports, 2015 - nature.com
Immunomagnetic assay combines the powers of the magnetic separation and biomarker
recognition and has been an effective tool to perform rare Circulating Tumor Cells detection …

Magnetic ranking cytometry: profiling rare cells at the single-cell level

M Labib, DN Philpott, Z Wang, C Nemr… - Accounts of chemical …, 2020 - ACS Publications
Conspectus Cellular heterogeneity in biological systems presents major challenges in the
diagnosis and treatment of disease and also complicates the deconvolution of complex …

Magnetic‐nanoparticle‐based immunoassays‐on‐chip: materials synthesis, surface functionalization, and cancer cell screening

Y Zhu, K Kekalo, C NDong, YY Huang… - Advanced Functional …, 2016 - Wiley Online Library
The unique properties of magnetic nanoparticles (MNPs), coupled with versatile surface
engineering techniques, have led to a rising class of screening methods that enable …

Quantification of non‐specific binding of magnetic micro‐and nanoparticles using cell tracking velocimetry: Implication for magnetic cell separation and detection

JJ Chalmers, Y Xiong, X Jin, M Shao… - Biotechnology and …, 2010 - Wiley Online Library
The maturation of magnetic cell separation technology places increasing demands on
magnetic cell separation performance. While a number of factors can cause sub‐optimal …

Quantitative magnetic separation of particles and cells using gradient magnetic ratcheting

C Murray, E Pao, P Tseng, S Aftab, R Kulkarni, M Rettig… - Small, 2016 - Wiley Online Library
Extraction of rare target cells from biosamples is enabling for life science research.
Traditional rare cell separation techniques, such as magnetic activated cell sorting, are …

Computational design optimization for microfluidic magnetophoresis

BD Plouffe, LH Lewis, SK Murthy - Biomicrofluidics, 2011 - pubs.aip.org
Current macro-and microfluidic approaches for the isolation of mammalian cells are limited
in both efficiency and purity. In order to design a robust platform for the enumeration of a …

Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation

M Unni, J Zhang, TJ George, MS Segal, ZH Fan… - Journal of colloid and …, 2020 - Elsevier
Isolation of cancer cells, bacteria, and viruses from peripheral blood has important
applications in cancer diagnosis, therapy monitoring, and drug development. Magnetic …

Microfluidic sorting of intrinsically magnetic cells under visual control

A Myklatun, M Cappetta, M Winklhofer… - Scientific Reports, 2017 - nature.com
Magnetic cell sorting provides a valuable complementary mechanism to fluorescent
techniques, especially if its parameters can be fine-tuned. In addition, there has recently …