Advanced thyroid cancer refers to thyroid tumors which are resistant to conventional
therapies and do not respond to radioiodine and comprises metastatic or recurrent …

Introduction: While the vast majority of patients with thyroid cancer have an excellent
prognosis, those with more aggressive courses experience significant morbidity and …

Differentiated thyroid carcinomas (DTCs) that arise from follicular cells account> 90% of
thyroid cancer (TC)[papillary thyroid cancer (PTC) 90%, follicular thyroid cancer (FTC) 10%] …

Opinion statement With a growing understanding of the biologic drivers of different thyroid
cancers, there is an ongoing revolution in the treatment of aggressive and advanced …

The incidence of thyroid cancer continues to increase and this neoplasia remains the most
common endocrine malignancy. No effective systemic treatment currently exists for iodine …

Advanced thyroid carcinoma is an infrequent tumor entity with limited treatment possibilities
until recently. The extraordinary improvement in the comprehension of genetic and …

Historically, systemic therapies for advanced, metastatic thyroid carcinomas have been
poorly effective. However, as a result of a confluence of increasing knowledge of the biologic …

Treatment of RAI-refractory DTC has rapidly evolved with advancements in tumor genomics.
Individualized treatment should consider specific tumor characteristics and balance the …

Several agents are currently being tested that target thyroid molecular signaling and cancer
cell biology. The pathways involved include but are not limited to the Ras pathway, vascular …

Introduction: Epigenetic changes have been detected in thyroid cancer cells, and evidence
indicates that they may contribute to altered differentiation and proliferation of these cells …