Folate-targeted iridium complexes amplify photodynamic therapy efficacy through ferroptosis

X He, L Wei, J Chen, S Ge… - Inorganic Chemistry …, 2023 - pubs.rsc.org
Interest in targeted cancer therapies with fewer side effects has increased in recent years.
Photodynamic therapy (PDT) involves the use of photosensitizers (PSs) and light to …

Oxygen-boosted biomimetic nanoplatform for synergetic phototherapy/ferroptosis activation and reversal of immune-suppressed tumor microenvironment

Z He, H Zhou, Y Zhang, X Du, S Liu, J Ji, X Yang… - Biomaterials, 2022 - Elsevier
Photodynamic therapy (PDT) induces apoptosis of cancer cells by generating cytotoxic
reactive oxygen species, the therapeutic effect of which, however, is impeded by …

Triggered all-active metal organic framework: ferroptosis machinery contributes to the apoptotic photodynamic antitumor therapy

X Meng, J Deng, F Liu, T Guo, M Liu, P Dai, A Fan… - Nano …, 2019 - ACS Publications
Nanoscale photodynamic therapy (PDT) is an appealing antitumor modality for which
apoptosis is the major mechanism of toxicity induction. It was postulated that the highly …

Cell membrane camouflaged Metal Oxide–Black Phosphorus Biomimetic Nanocomplex enhances photo-chemo-dynamic ferroptosis

K Chen, H Li, A Zhou, X Zhou, Y Xu… - ACS Applied Materials …, 2022 - ACS Publications
Despite the availability of various treatment options, the inherent complexity of tumors
significantly impairs therapeutic efficacy. Recently, combination treatments exhibited great …

Hydrazide/metal/indocyanine green coordinated nanoplatform for potentiating reciprocal ferroptosis and immunity against melanoma

G Hou, J Qian, Y Wang, W Xu, M Guo, Z Li… - … Applied Materials & …, 2023 - ACS Publications
Ferroptosis holds great potential in cancer treatment, but its efficacy is severely limited by a
low Fenton reaction efficacy. Meanwhile, the interactive relationship between Ferroptosis …

Engineering nanoenzymes integrating Iron-based metal organic frameworks with Pt nanoparticles for enhanced Photodynamic-Ferroptosis therapy

Y Ye, H Yu, B Chen, Y Zhao, B Lv, G Xue, Y Sun… - Journal of Colloid and …, 2023 - Elsevier
Photodynamic therapy (PDT), as a promising strategy in cancer treatment that utilizes
photosensitizers (PSs) to produce reactive oxygen species, has been widely used for …

Photo‐Enhanced Synergistic Induction of Ferroptosis for Anti‐Cancer Immunotherapy

Y Zhou, K Chen, WK Lin, J Liu, W Kang… - Advanced …, 2023 - Wiley Online Library
Ferroptosis as programmed cell death received considerable attention in cancer research.
Recently, studies have associated ferroptosis with photodynamic therapy (PDT) because …

Implanted, Wireless, Self‐Powered Photodynamic Therapeutic Tablet Synergizes with Ferroptosis Inducer for Effective Cancer Treatment

P Zou, R Lin, Z Fang, J Chen, H Guan, J Yin… - Advanced …, 2023 - Wiley Online Library
The effective and targeted treatment of resistant cancer cells presents a significant
challenge. Targeting cell ferroptosis has shown remarkable efficacy against apoptosis …

Complementing cancer photodynamic therapy with ferroptosis through iron oxide loaded porphyrin-grafted lipid nanoparticles

X Liang, M Chen, P Bhattarai, S Hameed, Y Tang… - ACS …, 2021 - ACS Publications
Nanomaterials that combine multimodality imaging and therapeutic functions within a single
nanoplatform have drawn extensive attention for molecular medicines and biological …

A Biodegradable Iridium (III) Coordination Polymer for Enhanced Two‐Photon Photodynamic Therapy Using an Apoptosis–Ferroptosis Hybrid Pathway

L Ke, F Wei, L Xie, J Karges, Y Chen… - Angewandte Chemie …, 2022 - Wiley Online Library
The clinical application of photodynamic therapy is hindered by the high glutathione
concentration, poor cancer‐targeting properties, poor drug loading into delivery systems …